Impact of oral hygiene on febrile neutropenia during breast cancer chemotherapy.
Impact of oral hygiene on febrile neutropenia during breast cancer chemotherapy.
复制标题
口腔卫生对乳腺癌化疗期间发热性中性粒细胞减少症的影响。
DOI：
10.1007/s12282-022-01410-9
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发表时间：
2023
期刊：
影响因子：
4
通讯作者：
Okada M
中科院分区：
文献类型：
--
作者：
Suzuki K;Sasada S;Nishi H;Kimura Y;Shintani T;Emi A;Masumoto N;Kadoya T;Kawaguchi H;Okada M
目的口腔卫生在癌症化疗期间口腔和发热并发症的处理中至关重要。本研究旨在探讨口腔卫生的影响对发热性中性粒细胞减少症（FN）的发病率在整个化疗过程中乳腺癌methodsA共137例乳腺癌患者进行了4个周期的辅助化疗与多西他赛和环磷酰胺（TC）联合治疗或多西他赛单独进行了评估，口腔卫生通过量化口腔细菌的数量，他们窝藏。这些患者接受了专业的口腔保健（POHC）。18例患者接受粒细胞集落刺激因子一级预防。口腔细菌计数和FN发病率之间的关系进行了回顾性assessed.ResultsThe FN发病率为47.4%，在所有治疗周期（32.8%，13.5%，14.3%，14.4%，在周期1，2，3，4，分别）。口腔细菌计数随着每个治疗周期而下降（周期1：9.10 × 106菌落形成单位（CFU）/mL，周期2：5.89 × 106 CFU/mL，周期3：4.61 × 106 CFU/mL，周期4：5.85 × 106 CFU/mL，P= 0.004）。在281个治疗周期中，63个（22.4%）发生FN。在治疗周期为基础的分析，高口腔细菌计数是一个独立的危险因素FN.ConclusionFN发病率下降，每个治疗周期，并与口腔细菌计数的变化。口腔细菌计数是乳腺癌FN发生的危险因素之一。
PurposeOral hygiene is crucial in the management of oral and febrile complications during chemotherapy for cancer. This study aimed to investigate the impact of oral hygiene on the incidence of febrile neutropenia (FN) throughout the course of chemotherapy for breast cancer.MethodsA total of 137 patients with breast cancer who underwent four cycles of adjuvant chemotherapy with docetaxel and cyclophosphamide (TC) combination therapy or docetaxel alone were assessed for oral hygiene by quantifying the number of oral bacteria they harbored. These patients received professional oral health care (POHC). Eighteen patients underwent primary prophylaxis with granulocyte colony-stimulating factors. The relationship between oral bacteria count and FN incidence was retrospectively assessed.ResultsThe FN incidence rate was 47.4% throughout all treatment cycles (32.8%, 13.5%, 14.3%, and 14.4% in cycles 1, 2, 3, and 4, respectively). The oral bacteria count decreased with each treatment cycle (cycle 1: 9.10 × 106colony-forming units (CFU)/mL, cycle 2: 5.89 × 106CFU/mL, cycle 3: 4.61 × 106CFU/mL, cycle 4: 5.85 × 106CFU/mL,P= 0.004). Among 281 treatment cycles, FN occurred in 63 (22.4%). In the treatment cycle-based analysis, high oral bacteria count was an independent risk factor for FN.ConclusionFN incidence decreased with each treatment cycle and was associated with changes in oral bacteria counts. The oral bacterial count was one of risk factors for FN development in breast cancer.