Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand
Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand
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DOI：
10.1086/313992
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发表时间：
2000-08-01
影响因子：
11.8
通讯作者：
Byth, K
中科院分区：
文献类型：
--
作者：
Chen, S;Sorrell, T;Byth, K
1994年至1997年间，澳大利亚和新西兰进行了一项基于人群的前瞻性研究，以阐明由新型隐球菌变种引起的隐球菌病的流行病学。新型隐球菌 (CNVN) 和 C, 新型隐球菌变种。 gattii (CNVG) 并将临床表现与宿主免疫状态和隐球菌多样性联系起来。每 10(6) 人口的平均年发病率在澳大利亚为 6.6，在新西兰为 2.2。在 312 次发作中，CNVN 引起 265 次（85%；免疫功能低下宿主中的 98% 发作），CNVG 引起 47 次（15%；免疫功能正常宿主中的 44% 发作）。澳大利亚艾滋病相关病例的发病率逐年下降（P
A prospective population-based study was conducted in Australia and New Zealand during 1994-1997 to elucidate the epidemiology of cryptococcosis due to Cryptococcus neoformans var. neoformans (CNVN) and C, neoformans var. gattii (CNVG) and to relate clinical manifestations to host immune status and cryptococcal variety. The mean annual incidence per 10(6) population was 6.6 in Australia and 2.2 in New Zealand, Of 312 episodes, CNVN caused 265 (85%; 98% of the episodes in immunocompromised hosts) and CNVG caused 47 (15%; 44% of the episodes in immunocompetent hosts). The incidence of AIDS-associated cases in Australia declined annually (P