Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study.
Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study.
复制标题
无先兆偏头痛患者的并发大脑结构和功能改变：一项功能磁共振成像研究
DOI：
10.1186/s10194-020-01203-5
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发表时间：
2020-12-07
期刊：
影响因子：
--
通讯作者：
Liang F
中科院分区：
文献类型：
--
作者：
Li Z;Zhou J;Lan L;Cheng S;Sun R;Gong Q;Wintermark M;Zeng F;Liang F
ObjectivesTo explore the possible concurrent brain functional and structural alterations in patients with migraine without aura (MwoA) patients compared to healthy subjects (HS).MethodsSeventy-two MwoA patients and forty-six HS were recruited. 3D-T1 and resting state fMRI data were collected during the interictal period for MwoA and HS. Voxel-based morphometry (VBM) for structure analysis and regional homogeneity (Reho) for fMRI analysis were applied. The VBM and Reho maps were overlapped to determine a possible brain region with concurrent functional and structural alteration in MwoA patients. Further analysis of resting state functional connectivity (FC) alteration was applied with this brain region as the seed.ResultsCompared with HS, MwoA patients showed decreased volume in the bilateral superior and inferior colliculus, periaqueductal gray matter (PAG), locus ceruleus, median raphe nuclei (MRN) and dorsal pons medulla junction. MwoA patients showed decreased Reho values in the middle occipital gyrus and inferior occipital gyrus, and increased Reho values in the MRN. Only a region in the MRN showed both structural and functional alteration in MwoA patients. Pearson correlation analysis showed that there was no association between volume or Reho values of the MRN and headache frequency, headache intensity, disease duration, self-rating anxiety scale or self-rating depression scale in MwoA patients. Resting state functional connectivity (FC) with the MRN as the seed showed that MwoA patients had increased FC between the MRN and PAG.ConclusionsMRN are involved in the pathophysiology of migraine during the interictal period. This study may help to better understand the migraine symptoms.Trial registrationNCT01152632 . Registered 27 June 2010.
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影响因子：
4.6
作者：
Li Z;Liu M;Lan L;Zeng F;Makris N;Liang Y;Guo T;Wu F;Gao Y;Dong M;Yang J;Li Y;Gong Q;Liang F;Kong J
通讯作者：
Kong J
影响因子：
4.9
作者：
Ayzenberg, Ilya;Nastos, Ilias;Krogias, Christos
通讯作者：
Krogias, Christos
影响因子：
4.9
作者：
Hougaard, Anders;Amin, Faisal M.;Ashina, Messoud
通讯作者：
Ashina, Messoud
影响因子：
9.9
作者：
Guitera, V;Muñoz, P;Pascual, J
通讯作者：
Pascual, J
影响因子：
3.4
作者：
Hubbard CS;Khan SA;Keaser ML;Mathur VA;Goyal M;Seminowicz DA
通讯作者：
Seminowicz DA