Context memories and reactivation: Constraints on the reconsolidation hypothesis
Context memories and reactivation: Constraints on the reconsolidation hypothesis
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DOI：
10.1037/0735-7044.118.5.956
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发表时间：
2004-10-01
影响因子：
1.9
通讯作者：
Rudy, JW
中科院分区：
文献类型：
--
作者：
Biedenkapp, JC;Rudy, JW
最近的证据表明，重新激活的情境恐惧记忆的维持需要海马体中依赖于蛋白质合成的重新巩固过程（K. Nader，2003）。相比之下，作者报告了一组系统的实验，但未能找到证据表明大鼠重新激活的上下文记忆变得不稳定，需要一种新的蛋白质来重新稳定。尽管在情境记忆重新激活后将蛋白质合成抑制剂注射到背侧海马或脑室内没有效果，但这些相同的治疗确实损害了情境记忆的初始巩固和情境恐惧记忆的巩固。这些结果表明，确定重新激活的记忆何时需要重新巩固可能存在重要的限制。作者针对这些限制的性质提出了 2 个假设。
Recent evidence suggests that the maintenance of a reactivated contextual-fear memory requires a protein-synthesis-dependent reconsolidation process in the hippocampus (K. Nader, 2003). In contrast, the authors report a systematic set of experiments that failed to find evidence that the rat's reactivated memory for context becomes labile and requires a new protein to restabilize. Although injecting the protein-synthesis inhibitor into the dorsal hippocampus or intracerebroventricularly following the reactivation of the context memory had no effect, these same treatments did impair the initial consolidation of the context memory and the consolidation of a contextual-fear memory. These results suggest that there may be important constraints determining when a reactivated memory requires reconsolidation. The authors offer 2 hypotheses about the nature of these constraints.