Progress in the use of gadolinium for NCT
Progress in the use of gadolinium for NCT
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DOI：
10.1016/j.apradiso.2009.03.109
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发表时间：
2009-07-01
影响因子：
1.6
通讯作者：
Daquino, G.
中科院分区：
文献类型：
--
作者：
Cerullo, N.;Bufalino, D.;Daquino, G.
在癌症治疗中使用钆的可能改善的评价，在参考钆在癌症治疗（GdNCT），进行了分析。首先对钆化合物的毒性问题进行了综述，确定了Motexafin钆是最好的。然后用一种特殊的方法计算了IC和俄歇电子的能谱。之后，该电子源被用作PENDENT PE代码的输入，并且在DNA中的能量存款被很好地定义。考虑到电子产额和能量分布与中子束谱和强度有关，通过计算研究优化了成形组件结构。最后，从两个不同的角度进行GdNCT的研究：使用MCNPX的宏观剂量学，与肿瘤和健康组织中的吸收剂量的计算，和使用PENNOPE的微剂量学，与通过能量存款的电子RBE的测定。将这两种数据结合起来确定等效剂量，引入治疗计划系统（TPS）中使用的特定优值。根据这些结果，GdNCT似乎是一种相当可能的肿瘤治疗方法。(C)2009爱思唯尔有限公司保留所有权利。
The evaluation of possible improvement in the use of Gd in cancer therapy, in reference to gadolinium in cancer therapy (GdNCT), has been analysed. At first the problem of the gadolinium compounds toxicity was reviewed identifying the Motexafin Gadolinium as the best. Afterwards, the spectrum of IC and Auger electrons was calculated using a special method. Afterwards, this electron source has been used as input of the PENELOPE code and the energy deposit in DNA was well defined. Taking into account that the electron yield and energy distribution are related to the neutron beam spectrum and intensity, the shaping assembly architecture was optimised through computational investigations. Finally the study of GdNCT was performed from two different points of view: macrodosimetry using MCNPX, with calculation of absorbed doses both in tumour and healthy tissues, and microdosimetry using PENELOPE, with the determination of electron RBE through the energy deposit. The equivalent doses were determined combining these two kinds of data, introducing specific figures of merit to be used in treatment planning system (TPS). According to these results, the GdNCT appears to be a fairly possible tumour therapy. (C) 2009 Elsevier Ltd. All rights reserved.