Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats
Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats
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DOI：
10.1016/j.pbb.2009.04.007
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发表时间：
2009-07-01
影响因子：
3.6
通讯作者：
Cain, Mary E.
中科院分区：
文献类型：
--
作者：
Coolon, Rosemary A.;Cain, Mary E.
与在贫乏条件（IC）中饲养的大鼠相比，在富集条件（EC）中饲养的大鼠对尼古丁的敏感性较低。然而，目前尚不清楚差异饲养对尼古丁引起的条件性多动有何影响。本研究确定了差异饲养是否会影响尼古丁引起的条件性多动。这项研究还研究了美加明对条件性多动和过敏的影响。 EC、IC 和社会状况 (SC) 大鼠在 21 至 51 天龄饲养，然后在 1 小时运动训练前接受重复尼古丁注射 (0.4 mg/kg)。在条件性多动测试之后，大鼠接受额外的训练，然后在致敏测试之前进行无药物休息期。在条件性多动试验和致敏试验之前给予美加明（1.0 mg/kg）。尼古丁治疗导致所有不同饲养组的过敏和条件性多动。 EC 大鼠对尼古丁的反应表现出比 IC 和 SC 大鼠更少的运动活动。美加明预处理仅在 EC 和 SC 大鼠中阻断了条件性多动的表达，并减弱了所有三个饲养组的致敏作用。这些发现表明，环境富集可能会改变发育过程中的烟碱乙酰胆碱受体，并且可能是吸烟行为开始和复发的保护因素。 (C) 2009 Elsevier Inc. 保留所有权利。
Rats reared in an enriched condition (EC) display less sensitization to nicotine than rats reared in an impoverished condition (IC). However, it is unknown what effect differential rearing has on nicotine-induced conditioned hyperactivity. The present study determined whether differential rearing affects nicotine-induced conditioned hyperactivity. This study also examined the effects of mecamylamine on conditioned hyperactivity and sensitization. EC, IC, and social condition (SC) rats were reared from 21 to 51 days of age before receiving repeated nicotine injections (.4 mg/kg) prior to 1-h locomotor sessions. Following the conditioned-hyperactivity test, rats received additional training sessions followed by a drug-free rest period before the sensitization test. Mecamylamine (1.0 mg/kg) was administered prior to the conditioned-hyperactivity test and sensitization test. Nicotine treatment resulted in sensitization and conditioned hyperactivity in all differential rearing groups. EC rats displayed less locomotor activity in response to nicotine than both IC and SC rats. Pretreatment with mecamylamine blocked the expression of conditioned hyperactivity only in EC and SC rats and attenuated sensitization in all three rearing groups. These findings suggest that environmental enrichment may alter nicotinic acetylcholine receptors during development and may be a protective factor in the initiation and relapse of smoking behavior. (C) 2009 Elsevier Inc. All rights reserved.