Peritoneal fluid gonadotropins and ovarian hormones in patients with ovarian cancer
Peritoneal fluid gonadotropins and ovarian hormones in patients with ovarian cancer
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DOI：
10.1046/j.1525-1438.1999.99075.x
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发表时间：
1999-11-01
影响因子：
4.8
通讯作者：
Schneider, D
中科院分区：
文献类型：
--
作者：
Halperin, R;Hadas, E;Schneider, D
本研究的目的是检查卵巢癌和对照患者腹膜液中的激素环境，并试图确定卵巢癌特异性的激素参数。本研究共纳入41例患者，其中卵巢癌患者21例，良性疾病患者20例，构成对照组。对这些患者的腹膜液和血清样本进行卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇的分析。（E-2），孕酮，睾酮，雄烯二酮和硫酸脱氢表雄酮（DHEAS），以及两个研究组之间的水平进行比较。此外，对腹膜液样本进行细胞学检查，并对血清样本进行ca125检测。腹膜液中所有检查的激素参数显示，与对照组相比，卵巢癌患者显著增加（P < 0.04）。两组间血清激素测量值无显著差异。为了进一步区分卵巢癌患者和非卵巢癌患者，计算各参数的敏感性、特异性、阳性预测值和阴性预测值以及诊断准确率。测定腹膜液LH的敏感性、特异性和诊断准确率均为100%。总之，与对照组相比，卵巢癌患者腹膜液中促性腺激素和卵巢激素水平显著升高，从而支持卵巢癌与特定激素环境相关的理论。此外，我们的研究结果提供了一种新的激素标记物来区分卵巢癌患者和非卵巢癌患者。
The aim of this study was to examine the hormonal milieu in peritoneal fluid in ovarian cancer and control patients, and to try to identify hormonal parameters specific for ovarian cancer. The study included 41 patients: 21 with ovarian cancer and 20 patients with benign disease, constituting a control group. The peritoneal fluid and serum samples from these patients were subjected to analysis of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol. (E-2), progesterone, testosterone, androstenedione, and dehydroepiandrosterone sulfate (DHEAS), and levels were compared between the two study groups.In addition, peritoneal fluid samples were subjected to cytologic examination and serum samples were assayed for CA 125. All the examined hormonal parameters in peritoneal fluid demonstrated a significant increase in ovarian cancer compared to control patients (P < 0.04). No significant difference in serum levels of the measured hormones was observed between the 2 groups. In order to further discriminate between patients with and without ovarian cancer, the sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy of each parameter were calculated. Determination of LH in peritoneal fluid provided sensitivity, specificity and diagnostic accuracy of 100%.In conclusion patients with ovarian cancer as compared to controls demonstrate significantly increased levels of gonadotropins and ovarian hormones in peritoneal fluid, thus supporting the theory of association between ovarian cancer and specific hormonal milieu. In addition, our results provide a novel hormonal marker for discrimination between patients with and without ovarian cancer.