Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence.
Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence.
复制标题
小鼠体温：酒精耐受性和身体依赖性的定量测量。
DOI：
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发表时间：
1976
影响因子：
3.5
通讯作者：
B. Tabakoff
中科院分区：
文献类型：
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作者：
R. Ritzmann;B. Tabakoff
在长期饮用酒精后戒断的小鼠被发现，如果保持在室温下，体温会降低。体温过低的程度与行为戒断症状有很好的相关性，可作为戒断综合征严重程度和时程的量化指标。把小鼠放在寒冷的环境(4摄氏度)会加剧体温过低，而将动物放在34摄氏度则会逆转体温过低而产生过高体温。结果表明，生理上依赖酒精的动物体温设定点机制和围绕该设定点的调节能力受到干扰。在食用含乙醇的饮食期间，小鼠表现出对急性剂量乙醇的低温影响的耐受性。对酒精低温效应的耐受性反映了行为耐受性的发展，这是通过在倾斜平面上的表现来衡量的。体温和行为耐受性都被显示出远远超过了戒断综合症的时期。乙醇处理的小鼠被发现对巴比妥酸盐的低温效应有交叉耐受性，但对单胺氧化酶抑制剂pargyline产生的低温没有耐受性。
Mice undergoing withdrawal after chronic ethanol consumption were found to be hypothermic if kept at room temperature. The extent of the hypothermia correlated well with the behavioral withdrawal symptoms and could be used as a quantitative measure of the severity and time course of the withdrawal syndrome. Placing mice in a cold environment (4 degrees C) exacerbated the hypothermia whereas placing animals at 34 degrees C reversed the hypothermia and produced hyperthermia. It was concluded that the temperature set point mechanism and the ability to regulate around this set point was disturbed in animals physically dependent on alcohol. During consumption of the ethanol-containing diets, mice exhibited tolerance to the hypothermic effects of an acutely administered dose od ethanol. Tolerance to the hypothermic effects of ethanol mirrored the development of behavioral tolerance as measured by performance on a tilting plane. Temperature and behavioral tolerance were both shown to extend well beyond the period of the withdrawal syndrome. Ethanol-treated mice were found to be cross-tolerant to the hypothermic effects of barbiturates but not to the hypothermia produced by the monoamine oxidase inhibitor, pargyline.