Non-Hodgkin lymphoma: the clinician's perspective-a view from the receiving end
Non-Hodgkin lymphoma: the clinician's perspective-a view from the receiving end
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DOI：
10.1038/modpathol.2012.184
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发表时间：
2013-01-01
期刊：
影响因子：
7.5
通讯作者：
Connors, Joseph M.
中科院分区：
文献类型：
--
作者：
Connors, Joseph M.
非霍奇金淋巴瘤的最佳治疗取决于建立准确的诊断和确定淋巴瘤的分期或解剖范围。有了这些信息，治疗的临床医生可以根据预期的自然史将淋巴瘤划分为一个亚组：惰性、侵袭性、急性白血病样或病毒性，这通常反映了未经治疗改变的疾病的典型行为，表明必须提供干预的紧迫性。最后，一些特殊的情况和问题所提出的具体淋巴瘤必须预期和治疗计划的改变，以适应他们。在初次治疗后，特殊的继发性事件，如转变为更具侵袭性的组织学类型必须被识别，并且必须改变治疗计划以解决这些事件。本文回顾了淋巴瘤的标准诊断分组，在初次诊断和随后的临床发展中遇到的特殊问题，并强调了血液病理学家和治疗临床医生之间的合作互动，这是最佳管理的基础。现代病理学杂志（2013）26,S111-S118；doi: 10.1038 / modpathol.2012.184
Optimal treatment of non-Hodgkin lymphoma depends on establishing an accurate diagnosis and determining the stage or anatomic extent of the lymphoma. With this information, the treating clinician can assign the lymphoma to a subgroup characterized by expected natural history: indolent, aggressive, acute leukemia-like or viral, which generally reflects the typical behavior of the disease unmodified by treatment and indicates the urgency with which intervention must be offered. Finally, a number of special circumstances and problems posed by specific lymphomas must be anticipated and the therapeutic plan altered to accommodate them. After primary treatment, special secondary events such as transformation to more aggressive histologic types must be recognized and the treatment plan must be altered to address these events. This article reviews standard diagnostic grouping of lymphomas, special problems encountered during primary diagnosis and subsequent clinical evolution and emphasizes the cooperative interaction between the hematopathologist and the treating clinician that underlies optimal management. Modern Pathology (2013) 26, S111-S118; doi:10.1038/modpathol.2012.184