Decoding brain state transitions in the pedunculopontine nucleus: cooperative phasic and tonic mechanisms
Decoding brain state transitions in the pedunculopontine nucleus: cooperative phasic and tonic mechanisms
复制标题
解码桥脚核中的大脑状态转换：合作的相位和强直机制
DOI：
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Juan Mena
中科院分区：
文献类型：
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作者：
A. Petzold;M. Valencia;B. Pál;Juan Mena
脚桥核（PPN）的胆碱能神经元在清醒状态下最活跃。它们的激活被认为会导致全球大脑活动从睡眠到觉醒的转变，而它们的持续放电可能有助于维持清醒状态并增强唤醒。类似地，非胆碱能PPN神经元对大脑状态转换有反应，并且它们的激活可能影响胆碱能神经元的一些相同靶点，这表明它们协调运作。然而，目前尚不清楚不同类别的PPN神经元在大脑状态下如何组织放电。在这里，我们监测在两个不同的水平的皮质动力学和它们的过渡在麻醉大鼠的PPN神经元的体内网络活动。我们确定了一个高度结构化的配置在PPN网络活动在慢波活动，被取代的去相关活动在激活状态（AS）。在过渡期间，神经元主要兴奋（相位或紧张性），但有些被抑制。识别胆碱能神经元显示阶段性和短潜伏期的感觉刺激的反应，而大多数的非胆碱能神经元表现出紧张性反应，并保持在高放电率超出状态转换。体外记录表明，胆碱能神经元表现出快速适应，防止它们在长时间内以高速率放电。我们的数据表明，PPN神经元在大脑状态转换过程中具有独特但互补的作用，其中胆碱能神经元对驱动状态转换的感觉事件提供快速和短暂的反应，而非胆碱能神经元在全局激活过程中保持较高的放电率。
Cholinergic neurons of the pedunculopontine nucleus (PPN) are most active during the waking state. Their activation is deemed to cause a switch in the global brain activity from sleep to wakefulness, while their sustained discharge may contribute to upholding the waking state and enhancing arousal. Similarly, non-cholinergic PPN neurons are responsive to brain state transitions and their activation may influence some of the same targets of cholinergic neurons, suggesting that they operate in coordination. Yet, it is not clear how the discharge of distinct classes of PPN neurons organize during brain states. Here, we monitored the in vivo network activity of PPN neurons in the anesthetized rat across two distinct levels of cortical dynamics and their transitions. We identified a highly structured configuration in PPN network activity during slow-wave activity that was replaced by decorrelated activity during the activated state (AS). During the transition, neurons were predominantly excited (phasically or tonically), but some were inhibited. Identified cholinergic neurons displayed phasic and short latency responses to sensory stimulation, whereas the majority of non-cholinergic showed tonic responses and remained at high discharge rates beyond the state transition. In vitro recordings demonstrate that cholinergic neurons exhibit fast adaptation that prevents them from discharging at high rates over prolonged time periods. Our data shows that PPN neurons have distinct but complementary roles during brain state transitions, where cholinergic neurons provide a fast and transient response to sensory events that drive state transitions, whereas non-cholinergic neurons maintain an elevated firing rate during global activation.
影响因子：
2.5
作者：
Meijun Ye;A. Hayar;E. Garcia-Rill
通讯作者：
Meijun Ye;A. Hayar;E. Garcia-Rill
影响因子：
5.6
作者：
Irmak, Simal Ozen;de Lecea, Luis
通讯作者：
de Lecea, Luis