Effects of concentrated ambient particles on heart rate, blood pressure, and cardiac Contractility in spontaneously hypertensive rats during a dust storm event
Effects of concentrated ambient particles on heart rate, blood pressure, and cardiac Contractility in spontaneously hypertensive rats during a dust storm event
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DOI：
10.1080/08958370701515399
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Cheng, Tsun-Jen
中科院分区：
文献类型：
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作者：
Chang, Chuen-Chau;Hwang, Jing-Shiang;Cheng, Tsun-Jen
流行病学研究表明，在亚洲沙尘事件期间，心血管死亡率和发病率增加。然而，这些发现仍然没有定论。我们已经证明，在沙尘暴事件中，患病动物的肺毒性增加。然而，沙尘暴颗粒的毒性性质尚不清楚。本研究的目的是在同一沙尘暴事件中，进一步研究高浓度PM2.5对自发性高血压大鼠心血管的影响。4只自发性高血压大鼠于10周龄时植入无线电遥测发射机。4周前收集基线心率、平均血压和心脏收缩能力(以QA间期衡量，QAI)数据。暴露组在沙尘暴过程中吸入浓缩性环境颗粒物6h，对照组同时吸入室内空气。在没有沙尘暴的情况下，在相同的时钟时间内，在事件发生后4周收集自身对照数据。重量分析表明，在暴露的6小时内，颗粒物的质量浓度为315.55微克/立方米。线性混合效应模型显示，在最初的潜伏期后，暴露期间心率(最大为93.8+/-18.8 bpm)和平均血压(最大为14.8+/-5.4 mm Hg)呈S形增加，QAI(最大为-3.5+/-1.5ms)呈S形下降。我们的结论是，与汽车燃烧过程中的产物不同，浓缩的沙尘暴颗粒物可能会对患病动物产生不良的心血管影响。
Epidemiological studies have suggested that cardiovascular mortality and morbidity increased during Asian dust events. The findings were still inconclusive though. We have shown an increased pulmonary toxicity in diseased animals during a dust storm event. However, the toxicity nature of dust storm particles remains unclear. It is our objective in this study to further investigate the cardiovascular effects of concentrated PM2.5 on spontaneously hypertensive rats during the same dust storm event. Four spontaneously hypertensive rats were implanted with radiotelemetry transmitters at the age of 10 wk. Baseline heart rate, mean blood pressure, and cardiac contractility (measured as QA interval, QAI) data were collected 4 wk before. Exposure group received concentrated ambient particles inhalation for 6 h during a dust storm event, while the control group received room air inhalation at the same time. Self-control data were collected 4 wk after the event during the same clock hours while there was no dust storm. Gravimetric analysis showed a particle mass concentration of 315.55 mu g/m(3) during the 6 h of exposure. A linear mixed-effects model revealed sigmoid increases in heart rate (to a maximum of 93.8 +/- 18.8 bpm) and mean blood pressure (to a maximum of 14.8 +/- 5.4 mm Hg), and a sigmoid decrease of QAI (to a maximum of -3.5 +/- 1.5 ms) during the exposure after an initial incubation period. We conclude that concentrated dust storm particles, which are different from products of automobile combustion process, may cause adverse cardiovascular effects on diseased animals.