Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals.
Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals.
复制标题
年轻和老年人类免疫缺陷病毒阳性个体之间的神经心理学测试概况差异。
DOI：
10.1080/13550280701258423
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发表时间：
2007
影响因子：
3.2
通讯作者：
Valcour,Victor
中科院分区：
文献类型：
--
作者：
Sacktor,Ned;Skolasky,Richard;Selnes,OlaA;Watters,Michael;Poff,Pamela;Shiramizu,Bruce;Shikuma,Cecilia;Valcour,Victor
Human immunodeficiency virus (HIV) dementia remains as an important cause of neurological morbidity among HIV-seropositive (HIV+) individuals. Differences in the neuropsychological profiles between older and younger HIV+ individuals have not been examined extensively. The objective of this study was to examine the neuropsychological test performance between old and young HIV+ individuals (a) with and without cognitive impairment (total cohort) and (b) with dementia. One hundred thirty-three older (age ≥ 50 years) HIV+ individuals and 121 younger (age 20 to 39 years) HIV+ individuals were evaluated with a standardized neuropsychological test battery. Differences between age groups in the mean z score for each neuropsychological test were determined. The older HIV+ (total) cohort had greater impairment in tests of verbal memory (P= .006), visual memory (P< .002), verbal fluency (P= .001), and psychomotor speed (P< .001) compared to the young HIV+ (total) cohort. After adjusting for differences in education, older HIV+ patients with dementia (n= 31) had a greater deficit in the Trail Making test Part B (P= 0.02) compared to younger HIV+ patients with dementia (n= 15). Age was associated with lower performance in tests of memory, executive functioning, and motor performance in older HIV+ individuals with and without cognitive impairment (total cohort), compared to younger HIV+ individuals. Among HIV+ patients with dementia, age may be associated with greater impairment in a test of executive functioning. These differences could be a result of advanced age itself or age-associated comorbidities such as coexisting cerebrovascular or neurodegenerative disease.
