Interleukin-17 family members in health and disease.
Interleukin-17 family members in health and disease.
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DOI：
10.1093/intimm/dxab075
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发表时间：
2021-11-25
影响因子：
4.4
通讯作者：
Iwakura Y
中科院分区：
文献类型：
--
作者：
Chung SH;Ye XQ;Iwakura Y
白细胞介素-17（IL-17）家族由6个成员（IL-17 A-IL-17 F）组成，其受体已全部鉴定。该家族主要通过诱导细胞因子和趋化因子、募集中性粒细胞、诱导抗微生物蛋白和修饰T辅助细胞分化参与宿主抵抗细菌、真菌和蠕虫感染的防御机制。IL-17 A和其他一些家族细胞因子也通过诱导炎性细胞因子和趋化因子参与银屑病、银屑病关节炎和强直性脊柱炎的发展，并且针对IL-17 A以及受体IL-17 RA的抗体正被成功地用于治疗这些疾病。在动物疾病模型中也表明参与炎症性肠病、多发性硬化症、类风湿性关节炎和肿瘤的发展。在这篇综述中，我们将简要回顾IL-17细胞因子参与这些疾病发展的机制，并讨论通过靶向IL-17家族成员治疗炎症性疾病的可能性。
The interleukin-17 (IL-17) family consists of six family members (IL-17A–IL-17F) and all the corresponding receptors have been identified recently. This family is mainly involved in the host defense mechanisms against bacteria, fungi and helminth infection by inducing cytokines and chemokines, recruiting neutrophils, inducing anti-microbial proteins and modifying T-helper cell differentiation. IL-17A and some other family cytokines are also involved in the development of psoriasis, psoriatic arthritis and ankylosing spondylitis by inducing inflammatory cytokines and chemokines, and antibodies against IL-17A as well as the receptor IL-17RA are being successfully used for the treatment of these diseases. Involvement in the development of inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and tumors has also been suggested in animal disease models. In this review, we will briefly review the mechanisms by which IL-17 cytokines are involved in the development of these diseases and discuss possible treatment of inflammatory diseases by targeting IL-17 family members.
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影响因子：
16.6
作者：
Akitsu A;Ishigame H;Kakuta S;Chung SH;Ikeda S;Shimizu K;Kubo S;Liu Y;Umemura M;Matsuzaki G;Yoshikai Y;Saijo S;Iwakura Y
通讯作者：
Iwakura Y
肿瘤浸润 T 辅助细胞 17 在人类结直肠癌中的双重作用。
影响因子：
24.5
作者：
Amicarella F;Muraro MG;Hirt C;Cremonesi E;Padovan E;Mele V;Governa V;Han J;Huber X;Droeser RA;Zuber M;Adamina M;Bolli M;Rosso R;Lugli A;Zlobec I;Terracciano L;Tornillo L;Zajac P;Eppenberger-Castori S;Trapani F;Oertli D;Iezzi G
通讯作者：
Iezzi G
影响因子：
64.8
作者：
Grivennikov, Sergei I.;Wang, Kepeng;Mucida, Daniel;Stewart, C. Andrew;Schnabl, Bernd;Jauch, Dominik;Taniguchi, Koji;Yu, Guann-Yi;Oesterreicher, Christoph H.;Hung, Kenneth E.;Datz, Christian;Feng, Ying;Fearon, Eric R.;Oukka, Mohamed;Tessarollo, Lino;Coppola, Vincenzo;Yarovinsky, Felix;Cheroutre, Hilde;Eckmann, Lars;Trinchieri, Giorgio;Karin, Michael
通讯作者：
Karin, Michael
DOI：
10.1084/jem.20111453
发表时间：
2012-08-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Coccia M;Harrison OJ;Schiering C;Asquith MJ;Becher B;Powrie F;Maloy KJ
通讯作者：
Maloy KJ
影响因子：
32.4
作者：
Chong, Wai Po;Mattapallil, Mary J.;Caspi, Rachel R.
通讯作者：
Caspi, Rachel R.