Selective lack of antibody to a component of EB nuclear antigen in patients with chronic active Epstein-Barr virus infection.
Selective lack of antibody to a component of EB nuclear antigen in patients with chronic active Epstein-Barr virus infection.
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慢性活动性 Epstein-Barr 病毒感染患者选择性缺乏针对 EB 核抗原成分的抗体。
DOI：
10.1093/infdis/156.1.26
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Henle,W
中科院分区：
文献类型：
--
作者：
Miller,G;Grogan,E;Rowe,D;Rooney,C;Heston,L;Eastman,R;Andiman,W;Niederman,J;Lenoir,G;Henle,W
12例慢性活动性EB病毒（EBV）感染患者血清中缺乏针对病毒DNA BamH Ⅰ K片段编码的EB病毒核抗原（EBNA）复合物的抗体。这种异常在18%的诊断为“慢性单核细胞增多症”的患者血清中检测到，与“疲劳综合征”患者（10%）相比，在具有客观临床表现和EBV复制抗原抗体滴度明显升高的严重疾病患者（132%）中更常见。K核抗原抗体的缺乏是特异性的，因为大多数没有K抗原抗体的人产生了对其他潜伏核（EBNA 2）抗原或核早期抗原的抗体。这样的患者能够裂解永生化细胞，释放核产物，并将其呈递给免疫系统。有三种假说可以解释K抗原抗体的缺乏：病毒突变、免疫识别失败或由于病毒广泛复制而导致抗原体内表达不足。缺乏针对EBNA一种成分的抗体可以作为某些慢性EB病毒感染患者的客观血清学标志物。
The sera of 12 patients with presumed chronic active Epstein-Barr virus (EBV) infection lacked antibody to a component of the Epstein-Barr nuclear antigen (EBNA) complex encoded by theBamHI K fragment of viral DNA. This anomaly, detected in ∼18% of sera obtained from patients with a diagnosis of “chronic mononucleosis,” was more often found in patients with severe disease (∼32%) who had objective clinical findings and markedly elevated antibody titers to EBV replicative antigens than in those patients with the “fatigue syndrome” (10%). The lack of antibody to the K nuclear antigen is specific because most of those who did not have antibody to the K antigen made antibody to other latent nuclear (EBNA 2) antigens or nuclear early antigens. Such patients are thus able to lyse immortalized cells, release nuclear products, and present them to the immune system. Three hypotheses are suggested to explain the lack of antibody to the K antigen: a viral mutation, a failure of immune recognition, or lack of in vivo expression of the antigen due to extensive viral replication. Lack of antibody to one component of EBNA may serve as an objective serological marker for certain patients with chronic EBV infection.