DURATION OF AMYOTROPHIC-LATERAL-SCLEROSIS IS AGE-DEPENDENT
DURATION OF AMYOTROPHIC-LATERAL-SCLEROSIS IS AGE-DEPENDENT
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DOI：
10.1002/mus.880160107
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发表时间：
1993-01-01
期刊：
影响因子：
3.4
通讯作者：
MAK, E
中科院分区：
文献类型：
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作者：
EISEN, A;SCHULZER, M;MAK, E
自1985年以来，我们前瞻性地随访了246例ALS患者。在138例死亡患者（86例男性和52例女性）中分析了发生神经功能缺损的年龄与疾病持续时间之间的关系。男性的平均病程为4.0 ± 3.8年，女性为3.2 ± 2.5年。发病年龄与病程呈指数反比关系（拟合优度P > 0.05）。发病年龄小于或等于40岁的患者平均病程为8.2 ± 5.0年，而61 - 70岁的患者为2.6 ± 1.4年（P > 0.001）。年轻人（小于或等于40岁）的男女比例为3.6：1。当年龄匹配时，病程是相同的患者与延髓和非延髓发作。我们的结论是，发病年龄，而不是性别，是决定ALS病程的最重要的预测因素。年轻患者的较长生存期可能反映了他们更大的神经元储备。
Since 1985, we prospectively followed 246 patients with ALS. The relationship between the age of developing neurological impairment and disease duration was analyzed in 138 patients (86 men and 52 women) who died. Mean disease duration was 4.0 +/- 3.8 years for men and 3.2 +/- 2.5 years for women. There was an inverse, exponential, relationship between onset age and duration (goodness-of-fit P > 0.05). Mean duration at onset age less-than-or-equal-to 40 years was 8.2 +/- 5.0 years compared with 2.6 +/- 1.4 years for patients aged 61 to 70 years (P > 0.001). The ratio of young (less-than-or-equal-to 40 years) men to women was 3.6:1. When matched for age, disease duration was the same for patients with bulbar and nonbulbar onsets. We conclude that onset age, but not sex, is the most significant predictor determining disesae duration in ALS. Longer survival in younger patients probably reflects their greater neuronal reserve.