TGF beta and IL13 in Schistosomiasis mansoni associated pulmonary arterial hypertension; a descriptive study with comparative groups.
TGF beta and IL13 in Schistosomiasis mansoni associated pulmonary arterial hypertension; a descriptive study with comparative groups.
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DOI：
10.1186/1471-2334-14-282
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发表时间：
2014-05-21
影响因子：
3.7
通讯作者：
Almeida MO
中科院分区：
文献类型：
--
作者：
Ferreira Rde C;Montenegro SM;Domingues AL;Bandeira AP;Silveira CA;Leite LA;Pereira Cde A;Fernandes IM;Mertens AB;Almeida MO
提示白细胞介素（IL）-13和转化生长因子（TGF）-β在血吸虫病动物模型肺血管改变中起作用。本研究的目的是评估和比较血吸虫病合并肺动脉高压（PAH）患者和血吸虫病不伴PAH患者血清总TGF-β和IL-13水平。来自Hospital das Clinicas，累西腓，伯南布哥，Brazil的血吸虫病门诊的34例患者（经超声心动图评估无PAH）和来自Pronto Socorro Cardiológico de伯南布哥，累西腓，Brazil的肺动脉高压参考中心的34例PAH患者（经右心导管插入术证实）入组研究。两组患者在腹部超声检查后均表现为门静脉周围纤维化。通过ELISA测定血清TGF-β 1和IL-13水平。独立样本采用Student t检验，非参数变量采用Mann-Whitney检验，相关性分析采用Pearson相关性检验，分类分析采用Fisher卡方检验。PAH患者的TGF-β 1中位值（22496.9 pg/ml，四分位距[IR] 15936.7 - 32087.8）显著高于非PAH患者（13629.9 pg/ml，IR：10192.2- 22193.8）（p = 0.006）。Sch-PAH组与非Sch-PAH组相比，IL-13中位数无差异（p > 0.05）。我们的研究结果表明，TGF-β可能发挥作用的发病机制与肺动脉高压相关。
It is suggested that interleukin (IL)-13 and transforming growth factor (TGF)-beta play a role in the pulmonary vascular changes found in animal models of schistosomiasis. The aim of this study was to assess and compare the serum levels of total TGF-beta and IL-13 of patients with schistosomiasis with pulmonary arterial hypertension (PAH) and patients with schistosomiasis without PAH. 34 patients from the schistosomiasis outpatient clinic of the Hospital das Clinicas, Recife, Pernambuco, Brazil, without PAH assessed by echocardiography and 34 patients from the Reference Centre of Pulmonary Hypertension of Pronto Socorro Cardiológico de Pernambuco, Recife, Brazil with PAH, confirmed by right heart catheterization, were enrolled on the study. Both groups presented with schistosomal periportal fibrosis after abdominal ultrasound. Serum levels of TGF-beta1 and IL-13 were determined by ELISA. Student t test to independent samples, Mann-Whitney test to nonparametric variables, Pearson correlation test for correlation analyses and Fisher Chi-squared test to compare categorical analyses were used. The median value of TGF-beta1 was significantly higher in patients with PAH (22496.9 pg/ml, interquartile range [IR] 15936.7 – 32087.8) than in patients without PAH (13629.9 pg/ml, IR: 10192.2- 22193.8) (p = 0.006). There was no difference in the median value of IL-13 in the group with Sch-PAH compared to patients without Sch-PAH (p > 0.05). Our results suggest that TGF-beta possibly plays a role in the pathogenesis of schistosomiasis-associated PAH.
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影响因子：
15.3
作者：
Daley, Eleen;Emson, Claire;Guignabert, Christophe;Malefyt, Rene de Waal;Louten, Jennifer;Kurup, Viswanath P.;Hogaboam, Cory;Taraseviciene-Stewart, Laimute;Voelkel, Norbert F.;Rabinovitch, Marlene;Grunig, Ekkehard;Grunig, Gabriele
通讯作者：
Grunig, Gabriele
影响因子：
6
作者：
Graham, Brian B.;Mentink-Kane, Margaret M.;Tuder, Rubin M.
通讯作者：
Tuder, Rubin M.
DOI：
10.1590/s0074-02762008000600009
发表时间：
2008-09-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Morais, Clarice Neuenschwander Lins de;Souza, Joelma Rodrigues de;Montenegro, Silvia Maria Lucena
通讯作者：
Montenegro, Silvia Maria Lucena
影响因子：
24
作者：
Barst, RJ;McGoon, M;Gaine, S
通讯作者：
Gaine, S
影响因子：
9.6
作者：
Price, Laura C.;Wort, S. John;Humbert, Marc
通讯作者：
Humbert, Marc