Serotonin is necessary for place memory in Drosophila
Serotonin is necessary for place memory in Drosophila
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DOI：
10.1073/pnas.0710168105
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发表时间：
2008-04-08
影响因子：
11.1
通讯作者：
Zars, Troy
中科院分区：
文献类型：
--
作者：
Sitaraman, Divya;Zars, Melissa;Zars, Troy
生物胺，如5-羟色胺和多巴胺，在加强联想学习方面可能很重要。通过操纵这两个信号中的任何一个来改变存储器性能，这一功能是显而易见的。在昆虫中，证据开始论证多巴胺在负面增强记忆中的共同作用。相比之下，5-羟色胺能系统在加强昆虫联想学习中的作用要么不清楚，要么有争议。我们研究了这两种信号在果蝇操纵性位置学习中的作用。通过基因改变5-羟色胺和多巴胺水平，操纵制造5-羟色胺和多巴胺的神经元，以及药物治疗，我们提供了明确的证据，证明位置记忆所必需的是5-羟色胺，而不是多巴胺。因此，5-羟色胺可能是昆虫记忆形成的关键，而多巴胺并不是一个普遍的负面强化信号。
Biogenic amines, such as serotonin and dopamine, can be important in reinforcing associative learning. This function is evident as changes in memory performance with manipulation of either of these signals. In the insects, evidence begins to argue for a common role of dopamine in negatively reinforced memory. In contrast, the role of the serotonergic system in reinforcing insect associative learning is either unclear or controversial. We investigated the role of both of these signals in operant place learning in Drosophila. By genetically altering serotonin and dopamine levels, manipulating the neurons that make serotonin and dopamine, and pharmacological treatments we provide clear evidence that serotonin, but not dopamine, is necessary for place memory. Thus, serotonin can be critical for memory formation in an insect, and dopamine is not a universal negatively reinforcing signal.