Breast Cancer and Use of Nonsteroidal Anti-inflammatory Drugs: A Meta-analysis
Breast Cancer and Use of Nonsteroidal Anti-inflammatory Drugs: A Meta-analysis
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DOI：
10.1093/jnci/djn324
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发表时间：
2008-10-15
影响因子：
10.3
通讯作者：
Etminan, Mahyar
中科院分区：
文献类型：
--
作者：
Takkouche, Bahi;Regueira-Mendez, Carlos;Etminan, Mahyar
背景乳腺癌是女性死亡的主要原因之一。使用非甾体抗炎药（NSAIDs）可能与降低乳腺癌风险有关，但这些相关性研究的结果并不一致。方法研究检查了乳腺癌风险与使用NSAIDs（包括阿司匹林和布洛芬）之间的关系，这些研究发表于1966年1月1日至2008年7月1日，使用Medline、EMBASE、和其他数据库。我们进行荟萃分析，根据其方差的倒数合并研究，并进行单独的分析，根据阿司匹林的使用和布洛芬的使用合并的研究。结果共纳入38项研究（16项病例对照研究，18项队列研究，3项嵌套在明确队列中的病例对照研究，1项临床试验），共纳入2788715例受试者。这些研究的结果表明，总体而言，NSAID的使用与乳腺癌风险降低相关（相对风险[RR] = 0.88，95%置信区间[CI] = 0.84至0.93）。阿司匹林（RR = 0.87，95%CI = 0.82至0.92）和布洛芬（RR = 0.79，95%CI = 0.64至0.97）的具体分析产生了类似的results.Conclusions这项荟萃分析提供的证据表明，NSAID的使用与乳腺癌的风险降低。未来的研究应包括仔细评估NSAIDs与乳腺癌之间关系的生物学机制。
Background Breast cancer is one of the leading causes of mortality among women. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with reduced risk for breast cancer, but results from these studies of the association have been inconsistent.Methods Studies that examined the association between risk of breast cancer and use of NSAIDs, including aspirin and ibuprofen, that were published between January 1, 1966, and July 1, 2008, were identified using Medline, EMBASE, and other databases. We performed meta-analysis by pooling studies according to the inverse of their variances and performed separate analyses of studies pooled according to aspirin use and ibuprofen use. We evaluated publication bias and study quality.Results A total of 38 studies (16 case-control studies, 18 cohort studies, 3 case-control studies nested in well-defined cohorts, and 1 clinical trial) that included 2 788 715 subjects were identified. The results of these studies suggest that overall, NSAID use was associated with reduced risk for breast cancer (relative risk [RR] = 0.88, 95% confidence interval [CI] = 0.84 to 0.93). Specific analyses for aspirin (RR = 0.87, 95% CI = 0.82 to 0.92) and ibuprofen (RR = 0.79, 95% CI = 0.64 to 0.97) yielded similar results.Conclusions This meta-analysis provides evidence that NSAID use is associated with reduced risk for breast cancer. Future research should include careful evaluation of the biologic mechanisms involved in the relationship between NSAIDs and breast cancer.