Diffusion tensor imaging of peripheral nerve in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a feasibility study
Diffusion tensor imaging of peripheral nerve in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a feasibility study
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DOI：
10.1007/s00234-010-0833-z
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发表时间：
2011-12-01
期刊：
影响因子：
2.8
通讯作者：
Awai, Kazuo
中科院分区：
文献类型：
--
作者：
Kakuda, Takako;Fukuda, Hiroshi;Awai, Kazuo
为探讨弥散张量成像（DTI）在慢性炎症性脱髓鞘性多神经根神经病（CIDP）患者中的临床应用价值，采用3 T磁共振成像仪对10例CIDP患者和10例性别、年龄相匹配的健康志愿者的胫神经进行了DTI扫描。我们制备了各向异性分数（FA）图，测量了胫神经的FA值，并比较了两个研究组的这些值。在9例患者中，我们还进行了胫神经传导检查，并分析了FA值与神经传导检查参数之间的相关性。（中位数0.401，范围0.312-0.510）显著低于健康志愿者（中值0.530，范围0.469-0.647）（Mann-Whitney检验，p < 0.01）。与动作电位波幅相关（斯皮尔曼相关系数，p = 0.04，r = 0.86），与神经传导速度相关性不显著（p = 0.79，r = 0.11）。
The purpose of this study was to assess the clinical feasibility of diffusion tensor imaging (DTI) for the evaluation of peripheral nerves in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).Using a 3-T magnetic resonance imaging scanner, we obtained DTI scans of the tibial nerves of 10 CIDP patients and 10 sex- and age-matched healthy volunteers. We prepared fractional anisotropy (FA) maps, measured the FA values of tibial nerves, and compared these values in the two study groups. In nine patients, we also performed tibial nerve conduction studies and analyzed the correlation between the FA values and parameters of the nerve conduction study.The tibial nerve FA values in CIDP patients (median 0.401, range 0.312-0.510) were significantly lower than those in healthy volunteers (median 0.530, range 0.469-0.647) (Mann-Whitney test, p < 0.01). They were significantly correlated with the amplitude of action potential (Spearman correlation coefficient, p = 0.04, r = 0.86) but not with nerve conduction velocity (p = 0.79, r = 0.11).Our preliminary data suggest that the noninvasive DTI assessment of peripheral nerves may provide useful information in patients with CIDP.