Three-dimensional printing of MRI-visible phantoms and MR image-guided therapy simulation.
Three-dimensional printing of MRI-visible phantoms and MR image-guided therapy simulation.
复制标题
MRI-Visible Phantoms和MR图像引导疗法模拟的三维印刷。
DOI：
10.1002/mrm.26136
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发表时间：
2017-02
影响因子：
3.3
通讯作者：
Mulkern, Robert V.
中科院分区：
文献类型：
--
作者：
Mitsouras, Dimitris;Lee, Thomas C.;Liacouras, Peter;Ionita, Ciprian N.;Pietilla, Todd;Maier, Stephan E.;Mulkern, Robert V.
演示解剖MRI-可视3D打印模型的使用，并评估过程的准确性和材料的MR信号特性。颈椎模型是由计算机断层扫描(CT)数据生成的，并使用MR信号生成材料进行3D打印。使用120KVP CT和3Tesla磁共振成像评估打印体模的准确性和信号特征。测量了制作的体模的MR弛豫速率和扩散系数，并获得了1H谱，以深入了解质子信号的性质。最后，在冷冻消融模型的过程中进行T2加权成像。打印模型产生的CT信号为102±8HU，MR信号约为短TE/短TRGRE MRI中生理盐水的1/3(456±36对1526±121个任意信号单位)。与活体CT扫描设计的模型相比，打印模型的CT相差0.13±0.11 mm，MR相差0.62±0.28 mm。打印材料的T2~32ms，T2*~7ms，T1~193ms，扩散系数小于橄榄油。冷冻消融的核磁共振监测显示，冰球的形成类似于体内的过程。目前的3D打印技术可以用于打印解剖上准确的模型，这些模型可以通过CT和MRI进行成像。这样的模型可以用来模拟核磁共振引导的干预措施，如冷冻手术。这项拟议技术的未来发展可能会导致打印模型的出现，这些模型描述了具有不同磁共振信号特征的不同组织和解剖结构。
To demonstrate the use of anatomic MRI-visible 3D-printed phantoms and to assess process accuracy and material MR signal properties. A cervical spine model was generated from Computed Tomography (CT) data and 3D-printed using an MR signal-generating material. Printed phantom accuracy and signal characteristics were assessed using 120 kVp CT and 3 Tesla MR imaging. The MR relaxation rates and diffusion coefficient of the fabricated phantom were measured and 1H spectra were acquired to provide insight into the nature of the proton signal. Finally, T2-weighted imaging was performed during cryoablation of the model. The printed model produced a CT signal of 102±8 HU, and an MR signal roughly 1/3rd that of saline in short-TE/short-TR GRE MRI (456±36 versus 1526±121 arbitrary signal units). Compared to the model designed from the in vivo CT scan, the printed model differed by 0.13±0.11 mm in CT, and 0.62±0.28 mm in MR. The printed material had T2~32 ms, T2*~7 ms, T1~193 ms, and a very small diffusion coefficient less than olive oil. MRI monitoring of the cryoablation demonstrated iceball formation similar to an in vivo procedure. Current 3D printing technology can be used to print anatomically accurate phantoms that can be imaged by both CT and MRI. Such models can be used to simulate MRI-guided interventions such as cryosurgeries. Future development of the proposed technique can potentially lead to printed models that depict different tissues and anatomical structures with different MR signal characteristics.
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影响因子：
3.3
作者：
Maier, Stephan E.;Mitsouras, Dimitris;Mulkern, Robert V.
通讯作者：
Mulkern, Robert V.
影响因子：
3
作者：
Khandelwal, Deepika;Hooda, Sunita;Shankar, Ravi
通讯作者：
Shankar, Ravi
影响因子：
3.8
作者：
Khandelwal, Deepika;Hooda, Sunita;Shankar, Ravi
通讯作者：
Shankar, Ravi
影响因子：
5.5
作者：
Kriz, J;Masar, B;Doskocilova, D
通讯作者：
Doskocilova, D
影响因子：
5
作者：
Bomers, Joyce G. R.;Sedelaar, J. P. Michiel;Futterer, Jurgen J.
通讯作者：
Futterer, Jurgen J.