Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells
Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells
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DOI：
10.1073/pnas.1513532112
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发表时间：
2015-10-13
影响因子：
11.1
通讯作者：
Jenkins, Marc K.
中科院分区：
文献类型：
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作者：
Linehan, Jonathan L.;Dileepan, Thamotharampillai;Jenkins, Marc K.
鼻腔(I.N.)感染优先产生Th17细胞。我们通过追踪来自粘膜病原体化脓性链球菌的MHC II类结合多肽的多克隆CD4(+)T细胞来探索这种解剖偏好的基础。化脓性链球菌MHC-II类结合多肽的CD4(+)T细胞首先在I.N后的颈淋巴结被激活。接种后分化为Th17细胞。化脓性葡萄球菌诱导的Th17的形成依赖于来自树突状细胞的转化生长因子-β1和来自CD301b(+)树突状细胞亚群的IL-6，该亚群位于颈部淋巴结而不是脾。因此，I.N.的趋势。诱导Th17细胞的感染与排出这一部位的特殊树突状细胞产生的细胞因子有关。
Intranasal (i.n.) infections preferentially generate Th17 cells. We explored the basis for this anatomic preference by tracking polyclonal CD4(+) T cells specific for an MHC class II-bound peptide from the mucosal pathogen Streptococcus pyogenes. S. pyogenes MHC class II-bound peptide-specific CD4(+) T cells were first activated in the cervical lymph nodes following i.n. inoculation and then differentiated into Th17 cells. S. pyogenes-induced Th17 formation depended on TGF-beta 1 from dendritic cells and IL-6 from a CD301b(+) dendritic cell subset located in the cervical lymph nodes but not the spleen. Thus, the tendency of i.n. infection to induce Th17 cells is related to cytokine production by specialized dendritic cells that drain this site.