Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a β3-adrenoceptor agonist
Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a β3-adrenoceptor agonist
复制标题
DOI：
10.1016/j.ejphar.2005.06.004
复制
发表时间：
2005-07-25
影响因子：
5
通讯作者：
Akahane, M
中科院分区：
文献类型：
--
作者：
Oana, F;Takeda, H;Akahane, M
我们的目的是确定β 3肾上腺素受体激动剂对db/db小鼠血浆脂联素水平和脂联素、脂联素受体1和脂联素受体2 mRNA表达水平的影响。CL-316，243经口给药2周后，血红蛋白A1 c、葡萄糖、胰岛素、甘油三酯和游离脂肪酸的血浆水平降低，血浆脂联素水平升高。它还改善了口服葡萄糖耐量试验中的胰岛素抵抗。CL-316，243给药组附睾白色脂肪组织中脂联素mRNA表达显著高于对照组，但棕色脂肪组织、比目鱼肌或肝脏中脂联素mRNA表达不显著。仅CL-316，243给药组肝脏中脂联素受体2 mRNA表达显著降低（与对照组相比）。这些结果表明，在接受该β（3）-肾上腺素受体激动剂给药的db/db小鼠中观察到的血浆脂联素水平升高可特异性诱导肝脏中脂联素受体2 mRNA表达下调。(c)2005 Elsevier B.V保留所有权利。
Our aim was to determine the effect of a beta(3)-adrenoceptor agonist on plasma adiponectin levels and on the level of expression of mRNA for adiponectin, adiponectin receptor 1, and adiponectin receptor 2 in db/db mice. Two weeks' oral administration of CL-316,243 led to decreased plasma levels of hemoglobin A1c, glucose, insulin, triglyceride and free fatty acid, and to an increased plasma adiponectin levels. It also improved insulin resistance in the oral glucose tolerance test. Adiponectin mRNA expression was significantly higher in the CL-316,243-treatment group than in the control group in epididymal white adipose tissue but not in brown adipose tissue, soleus muscle or liver. Adiponectin receptor 2 mRNA expression was significantly lower only in the liver of the CL-316,243-treatment group (versus the control group).These results suggest that the increased plasma adiponectin levels seen in db/db mice treated with this beta(3)-adrenoceptor agonist induce a down-regulation of adiponectin receptor 2 mRNA expression specifically in the liver. (c) 2005 Elsevier B.V All rights reserved.