THE IMMUNOGLOBULINS OF MICE. V. THE METABOLIC (CATABOLIC) PROPERTIES OF FIVE IMMUNOGLOBULIN CLASSES.
THE IMMUNOGLOBULINS OF MICE. V. THE METABOLIC (CATABOLIC) PROPERTIES OF FIVE IMMUNOGLOBULIN CLASSES.
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小鼠的免疫球蛋白。 V.五个免疫球蛋白类别的代谢（分解代谢）特性。
DOI：
10.1084/jem.122.1.41
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发表时间：
1965-07-01
影响因子：
15.3
通讯作者：
SELL, S
中科院分区：
文献类型：
--
作者：
FAHEY, J L;SELL, S
通过比较五类小鼠免疫球蛋白来研究免疫球蛋白的代谢特性。三种形式的 7S 免疫球蛋白具有不同的分解代谢率。 7S γ2a-球蛋白的分解代谢分数率约为每天 13%； 7S γ2b-球蛋白为 25%； 7S γ1-球蛋白为 17%。三类 7S γ-球蛋白（γ2a、γ2b 和 γ1）的分解代谢在低血清 7S γ-球蛋白水平时延长，在高血清 7S γ-球蛋白水平时加速。每种7S γ-球蛋白成分均受到其他小鼠7S γ-球蛋白成分的血清水平和外源施用的人7S γ-球蛋白的影响。然而，IgA（γ1A-、β2A-球蛋白）的血清水平并未明显改变它们。在正常 IgG（7S γ-球蛋白）周转研究中观察到的逐渐变化（更长）的半衰期可能是由正常 7S 免疫球蛋白的分解代谢异质性引起的，这些免疫球蛋白在免疫化学和分解代谢上与 γ2a-、γ2b- 和 7S γ1-骨髓瘤蛋白相关。这些研究表明 7S γ2a-、7S γ2b- 和 7S γ1-球蛋白具有共同的分解代谢控制机制。该机制受到每种成分的血清水平的影响，但独立于 IgA（γ1A-球蛋白）的血清水平，并且可能独立于 IgM（γ1M-球蛋白）。 IgA（γ1A-、β2A-球蛋白）和 IgM（γ1M-球蛋白）的分解代谢比 7S γ-球蛋白的分解代谢快得多。 IgA 和 IgM 的半衰期分别约为 1.2 和 0.5 天。 IgA 和 IgM 分解代谢的分数率似乎与其血清浓度无关。研究表明，分解代谢速率以及合成速率在确定各类免疫球蛋白的血清水平中发挥着重要作用。
The metabolic properties of immunoglobulin were investigated by comparing five classes of mouse immunoglobulin. Three forms of 7S immunoglobulin had different rates of catabolism. The fractional rates of catabolism were found to be about 13 per cent per day for 7S γ2a-globulin; 25 per cent for 7S γ2b-globulin; and 17 per cent for 7S γ1-globulin. Catabolism of the three classes of 7S γ-globulin (γ2a, γ2b, and γ1) were prolonged at low serum 7S γ-globulin levels and accelerated at high serum 7S γ-globulin levels. Each of the 7S γ-globulin components was influenced by the serum level of the other mouse 7S γ-globulin components and by exogenously administered human 7S γ-globulin. They were not appreciably altered, however, by the serum level of IgA (γ1A-, β2A-globulin). The progressively changing (longer) half-times observed in turnover studies of normal IgG (7S γ-globulin) may be caused by catabolic heterogeneity of normal 7S immunoglobulins which are immunochemically and catabolically related to γ2a-, γ2b-, and 7S γ1-myeloma proteins. These studies indicate that the 7S γ2a-, 7S γ2b-, and 7S γ1-globulins share a common catabolic control mechanism. This mechanism is influenced by the serum level of each of these components, but is independent of the serum level of IgA (γ1A-globulin) and probably is independent of IgM (γ1M-globulin). Catabolism of IgA (γ1A-, β2A-globulin) and IgM (γ1M-globulin) was much more rapid than the catabolism of the 7S γ-globulins. The halftimes of the IgA and IgM were approximately 1.2 and 0.5 days respectively. The fractional rate of catabolism of IgA and IgM seemed to be independent of their serum concentration. The rate of catabolism, as well as the rate of synthesis, was shown to play a major role in determining the serum level of each class of immunoglobulin.