Oral microbiota in patients with atherosclerosis
Oral microbiota in patients with atherosclerosis
复制标题
DOI：
10.1016/j.atherosclerosis.2015.10.097
复制
发表时间：
2015-12-01
期刊：
影响因子：
5.3
通讯作者：
Backhed, Fredrik
中科院分区：
文献类型：
--
作者：
Fak, Frida;Tremaroli, Valentina;Backhed, Fredrik
背景和目标：最近的证据表明，微生物群可能被认为是一个环境因素，有助于动脉粥样硬化的发展。牙周病与心脑血管事件有关，牙周组织的炎症被认为会增加宿主的全身炎症水平，这反过来又会影响斑块的组成和破裂。我们之前的研究表明，动脉粥样硬化斑块中可以发现来自口腔和肠道的细菌。方法：为了阐明无症状和有症状动脉粥样硬化患者的口腔微生物群组成是否不同，我们对92名个体的口腔微生物群进行了焦磷酸测序，其中包括无症状和有症状动脉粥样硬化患者以及没有颈动脉斑块或既往中风或心肌梗死的对照个体。结果：对照组和动脉粥样硬化患者的总体微生物结构相似，但有症状的动脉粥样硬化患者的厌氧菌相对丰度（平均0.040%（SD 0.049））高于对照组（0.010%（SD 0.028））（P = 0.03）。通过线性回归分析发现，微单胞菌与uCRP呈正相关，二氧化碳噬纤维菌、卡托尼菌和乳酸菌与血脂指标呈正相关。总之，口腔内厌氧球菌的丰度可能与有症状的动脉粥样硬化有关。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Background and aims: Recent evidence suggests that the microbiota may be considered as an environmental factor that contributes to the development of atherosclerosis. Periodontal disease has been associated with cardio- and cerebrovascular events, and inflammation in the periodontium is suggested to increase the systemic inflammatory level of the host, which may in turn influence plaque composition and rupture. We previously showed that bacteria from the oral cavity and the gut could be found in atherosclerotic plaques.Methods: To elucidate whether the oral microbiota composition differed between patients with asymptomatic and symptomatic atherosclerosis we performed pyrosequencing of the oral microbiota of 92 individuals including patients with asymptomatic and symptomatic atherosclerosis and control individuals without carotid plaques or previous stroke or myocardial infarction.Results: The overall microbial structure was similar in controls and atherosclerosis patients, but patients with symptomatic atherosclerosis had higher relative abundance of Anaeroglobus (mean 0.040% (SD 0.049)) than the control group (0.010% (SD 0.028)) (P = 0.03). Using linear regression analysis, we found that Parvimonas associated positively with uCRP and Capnocytophaga, Catonella and Lactobacillus associated with blood lipid markers. In conclusion, abundance of Anaeroglobus in the oral cavity could be associated with symptomatic atherosclerosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.