STRUCTURE OF A NOVEL CA-2+ AND CALMODULIN-DEPENDENT CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE INHIBITOR KS-619-1
STRUCTURE OF A NOVEL CA-2+ AND CALMODULIN-DEPENDENT CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE INHIBITOR KS-619-1
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DOI：
10.7164/antibiotics.40.1111
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发表时间：
1987-08-01
影响因子：
3.3
通讯作者：
SANO, H
中科院分区：
文献类型：
--
作者：
YASUZAWA, T;YOSHIDA, M;SANO, H
KS-619-1是钙离子和钙调素依赖性环核苷酸磷酸二酯酶的有效抑制剂。通过对KS-619-1及其甲基衍生物的光谱研究，确定其结构为8，13-二氧代-3-（2-氧代丙基）-5，6，8，13-四氢-1，7，9，11-四羟基苯并[a]萘-2-羧酸。
The structure of KS-619-1, a potent inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was determined to be 8,13-dioxo-3-(2-oxopropyl)-5,6,8,13-tetrahydro-1,7,9,11-tetrahydroxybenz[a]naphtacene-2-carboxylic acid by spectral studies of KS-619-1 and its methyl derivative.