Humoral responses to SARS-CoV-2 by healthy and sick dogs during the COVID-19 pandemic in Spain.
Humoral responses to SARS-CoV-2 by healthy and sick dogs during the COVID-19 pandemic in Spain.
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DOI：
10.1186/s13567-021-00897-y
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发表时间：
2021-02-15
影响因子：
4.4
通讯作者：
Barbero-Fernández A
中科院分区：
文献类型：
--
作者：
Perisé-Barrios AJ;Tomeo-Martín BD;Gómez-Ochoa P;Delgado-Bonet P;Plaza P;Palau-Concejo P;González J;Ortiz-Díez G;Meléndez-Lazo A;Gentil M;García-Castro J;Barbero-Fernández A
COVID-19是由SARS-CoV-2引起的人畜共患疾病。最近报告了动物感染SARS-CoV-2的情况，西班牙兽医也发现家犬严重肺部病变的增加。因此，进一步描述那些表现出与受COVID-19影响的人类相似症状的动物的病理过程将非常有价值。伴侣动物可能导致这种已知的人传人疾病的持续传播和社区传播，这是一个亟待考虑的问题。通过胸部X线、超声分析和计算机断层扫描研究了40只具有肺部病理的动物。分析鼻咽和直肠拭子以检测犬病原体，包括SARS-CoV-2。另外20只生活在SARS-CoV-2阳性家庭的健康狗也被纳入。通过几种免疫测定法进行免疫球蛋白检测。我们的研究结果表明，患病犬表现为严重的肺泡或间质型肺混浊，实质异常，和双边病变。40只病犬SARS-CoV-2均为阴性，但支原体属（Mycoplasma spp.）在33只狗中的26只中检测到。5只健康犬和1只病理犬均呈现抗SARS-CoV-2的IgG抗体。在这里，我们报告说，尽管检测到狗与α-SARS-CoV-2 IgG，我们从来没有得到一个阳性的RT-qPCR的SARS-SoV-2，甚至没有在狗与严重的肺部疾病;这表明，即使在犬感染的情况下，传播是不可能的。此外，生活在COVID-19阳性家庭的狗可能更容易感染SARS-CoV-2。
COVID-19 is a zoonotic disease caused by SARS-CoV-2. Infections of animals with SARS-CoV-2 have recently been reported, and an increase of severe lung pathologies in domestic dogs has also been detected by veterinarians in Spain. Therefore, further descriptions of the pathological processes in those animals that show symptoms similar to those described in humans affected by COVID-19 would be highly valuable. The potential for companion animals to contribute to the continued transmission and community spread of this known human-to-human disease is an urgent issue to be considered. Forty animals with pulmonary pathologies were studied by chest X-ray, ultrasound analysis, and computed tomography. Nasopharyngeal and rectal swabs were analyzed to detect canine pathogens, including SARS-CoV-2. An additional twenty healthy dogs living in SARS-CoV-2-positive households were included. Immunoglobulin detection by several immunoassays was performed. Our findings show that sick dogs presented severe alveolar or interstitial patterns with pulmonary opacity, parenchymal abnormalities, and bilateral lesions. The forty sick dogs were negative for SARS-CoV-2 but Mycoplasma spp. was detected in 26 of 33 dogs. Five healthy and one pathological dog presented IgG against SARS-CoV-2. Here we report that despite detecting dogs with α-SARS-CoV-2 IgG, we never obtained a positive RT-qPCR for SARS-SoV-2, not even in dogs with severe pulmonary disease; suggesting that even in the case of canine infection, transmission would be unlikely. Moreover, dogs living in COVID-19-positive households could have been more highly exposed to infection with SARS-CoV-2.
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影响因子：
158.5
作者：
Li, Qun;Guan, Xuhua;Feng, Zijian
通讯作者：
Feng, Zijian
DOI：
10.1016/j.cvsm.2008.02.008
发表时间：
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通讯作者：
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影响因子：
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通讯作者：
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DOI：
10.1016/j.cvsm.2019.10.009
发表时间：
2020-03-01
影响因子：
1.9
作者：
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通讯作者：
Reagan, Krystle L.