Effects of sleep deprivation on autonomic and endocrine functions throughout the day and on exercise tolerance in the evening
Effects of sleep deprivation on autonomic and endocrine functions throughout the day and on exercise tolerance in the evening
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DOI：
10.1080/02640414.2012.733824
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发表时间：
2013-02
影响因子：
3.4
通讯作者：
Masayuki Konishi;Masaki Takahashi;Naoya Endo;Shigeharu Numao;Shun Takagi;M. Miyashita;T. Midorikawa;Katsuhiko Suzuki;S. Sakamoto
中科院分区：
文献类型：
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作者：
Masayuki Konishi;Masaki Takahashi;Naoya Endo;Shigeharu Numao;Shun Takagi;M. Miyashita;T. Midorikawa;Katsuhiko Suzuki;S. Sakamoto
摘要本研究旨在探讨睡眠剥夺对白天自主神经和内分泌功能以及晚上运动耐量的影响。10名健康的年轻男性完成了两项为期2天的控制和睡眠剥夺试验。对于对照试验，参与者被允许从23：00到07：00正常睡眠。在睡眠剥夺试验中，参与者34小时不睡觉。自主神经活动的测量从19：00 h的第1天到16：00 h的第2天的心率变异性的频域措施。通过测量第2天09：00、13：00和17：00 h以及运动耐量试验后立即采集的静脉血样中的促肾上腺皮质激素和皮质醇，检查内分泌功能。自主神经调节，特别是副交感神经调节估计的高频成分的心率变异性分析，是显着高于在睡眠剥夺试验中的控制试验在上午和下午的第2天。血浆促肾上腺皮质激素浓度显着高于09：00和13：00小时的睡眠剥夺下的第2天。运动时的心率在睡眠剥夺后显著降低。因此，睡眠剥夺对自主神经调节的影响取决于一天中的时间。
Abstract The aim of this study was to investigate the effects of sleep deprivation on autonomic and endocrine functions during the day and on exercise tolerance in the evening. Ten healthy young males completed two, 2-day control and sleep deprivation trials. For the control trial, participants were allowed normal sleep from 23:00 to 07:00 h. For the sleep deprivation trial, participants did not sleep for 34 h. Autonomic activity was measured from 19:00 h on day 1 to 16:00 h on day 2 by frequency-domain measures of heart rate variability. Endocrine function was examined by measuring adrenocorticotropic hormone and cortisol from venous blood samples collected on day 2 at 09:00, 13:00, and 17:00 h and immediately after an exercise tolerance testing. Autonomic regulation, particularly parasympathetic regulation estimated from the high-frequency component of heart rate variability analysis, was significantly higher in the sleep deprivation trial than in the control trial in the morning and afternoon of day 2. Plasma adrenocorticotropic hormone concentrations were significantly higher at 09:00 and 13:00 h of day 2 under sleep deprivation. Heart rate during exercise was significantly lower following sleep deprivation. Therefore, the effects of sleep deprivation on autonomic regulation depend on the time of the day.