Human H1 histones: conserved and varied sequence elements in two H1 subtype genes.
Human H1 histones: conserved and varied sequence elements in two H1 subtype genes.
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人类 H1 组蛋白：两个 H1 亚型基因中保守且变化的序列元件。
DOI：
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发表时间：
1989
影响因子：
6.6
通讯作者：
D. Doenecke
中科院分区：
文献类型：
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作者：
S. Eick;M. Nicolai;D. Mumberg;D. Doenecke
分离了两种不同人类H1组蛋白的编码基因，并从核苷酸序列中推断了其一级结构。这些基因彼此不同，也不同于到目前为止所描述的任何其他脊椎动物的H1结构。差异主要发生在N端和C端的H1结构域，而蛋白质的中心部分是高度保守的。然而，在侧翼结构域中，一些序列元件由不同的H1亚型基因共享。在两个H1亚型中都发现了一个八肽，它已经在大多数H1组蛋白的C-末端结构域中被描述过。这两个H1基因侧翼部分的核苷酸序列在已建立的调控位点上显示了保守的基序，但除此之外，这两个基因的3‘和5’非编码序列有很大的不同。
The genes coding for two different human H1 histones were isolated, and the primary structures were deduced from the nucleotide sequences. The genes differ from each other and from any other vertebrate H1 structure described until now. The differences occur mainly within the N- and C-terminal H1 domains, whereas the central part of the protein is highly conserved. Within the flanking domains, however, some sequence elements are shared by different H1 subtype genes. An octapeptide, which has been described in C-terminal domains of most H1 histones, is found in both H1 subtypes. The nucleotide sequences of the flanking portions of both H1 genes show conserved motifs at established regulatory sites, but otherwise these 3' and 5' noncoding sequences of both genes differ substantially.