The effect of respiratory carcinogenesis on systemic humoral and cell-mediated immunity of Syrian golden hamsters.
The effect of respiratory carcinogenesis on systemic humoral and cell-mediated immunity of Syrian golden hamsters.
复制标题
呼吸道癌变对叙利亚金仓鼠全身体液和细胞免疫的影响。
作者：
B. Zwilling
评估了气管内滴注苯并（a）芘及其非致癌类似物苯并（a）芘对叙利亚金仓鼠全身体液和细胞介导的免疫反应的影响。与类似物处理的对照组相比，用致癌物处理的仓鼠对绵羊红细胞的脾斑形成细胞反应有短暂的抑制。直接（免疫球蛋白 M）和间接（免疫球蛋白 G）噬斑形成细胞的数量在治疗第 9 周受到抑制，然后恢复到对照水平。通过中国仓鼠皮肤移植物的排斥反应评估，没有发现细胞介导的免疫反应受到抑制。
The effect of intratracheal instillation of benzo(a)pyrene and its noncarcinogenic analog benzo(a)pyrene on the systemic humoral and cell-mediated immune response of Syrian golden hamsters was evaluated. Hamsters treated with the carcinogen had a transient suppression of the splenic plaque-forming cell response to sheep erythrocytes, compared with analog-treated controls. The numbers of direct (immunoglobulin M) and indirect (immunoglobulin G) plaque-forming cells were suppressed at the 9th week of treatment and then recovered to control levels. No suppression in the cell-mediated immune response, as assessed by the rejection of Chinese hamster skin grafts, was found.