Associations of extracranial carotid atherosclerosis progression with coronary status and risk factors in patients with and without coronary artery disease
Associations of extracranial carotid atherosclerosis progression with coronary status and risk factors in patients with and without coronary artery disease
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DOI：
10.1161/01.cir.0000033833.54884.34
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发表时间：
2002-10-15
期刊：
影响因子：
37.8
通讯作者：
Mercuri, M
中科院分区：
文献类型：
--
作者：
Crouse, JR;Tang, R;Mercuri, M
颅外颈动脉内膜中层厚度（IMT）与冠状动脉疾病（CAD）和CAD危险因素有关。很少有研究探讨了危险因素与IMT进展的关系，没有评估其与IMT进展的关系，特别是在有和无CAD的患者中。方法和结果-我们使用冠状动脉造影确定了280例患者，男女各半，冠状动脉狭窄大于或等于50%或无CAD。在基线时测量风险因素，并在基线时测量IMT，并每年对其中241人进行3年测量。基线危险因素和CAD状态与IMT进展相关。CAD患者的IMT进展比无CAD患者快3倍（平均值± SEM，33.7 ± 7.4 vs 8.9 ± 7.1 μ m/年; P=0.02），CAD状态和高密度脂蛋白（HDL）胆固醇与IMT进展独立相关。男性，增加腰臀比，吸烟，增加甘油三酯，降低HDL胆固醇与增加进展CAD patients. Conclusion-CAD患者有更快的进展IMT比CAD无控制，和危险因素与他们的进展。
Background-Intimal medial thickness of the extracranial carotid arteries (IMT) is related to coronary artery disease (CAD) and CAD risk factors. Few studies have explored the association of risk factors with progression of IMT, and none have evaluated their associations with IMT progression specifically in patients with and without CAD.Methods and Results-We used coronary angiography to identify 280 patients equally divided between men and women and those with either greater than or equal to50% coronary artery stenosis or no CAD. Risk factors were measured at baseline and IMT was measured at baseline and yearly for 3 years in 241 of these individuals. Baseline risk factors and CAD status were related to IMT progression. IMT of patients with CAD progressed 3 times faster than that of patients with no CAD (mean+/-SEM, 33.7+/-7.4 versus 8.9+/-7.1 mum/year; P=0.02), and CAD status and high-density lipoprotein (HDL) cholesterol were independently associated with IMT progression. Male sex, increased waist to hip ratio, cigarette smoking, increased triglycerides, and decreased HDL cholesterol were associated with increased progression in CAD patients.Conclusions-Patients with CAD have more rapid progression of IMT than CAD-free controls, and risk factors are related to progression in them.