Perinatal morbidity and risk of hypoxic-ischemic encephalopathy associated with intrapartum sentinel events
Perinatal morbidity and risk of hypoxic-ischemic encephalopathy associated with intrapartum sentinel events
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DOI：
10.1016/j.ajog.2011.09.031
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发表时间：
2012-02-01
影响因子：
9.8
通讯作者：
Garcia-Alix, Alfredo
中科院分区：
文献类型：
--
作者：
Martinez-Biarge, Miriam;Madero, Rosario;Garcia-Alix, Alfredo
目的：研究设计：2000-2005年的回顾性队列研究。比较了3组暴露于不同围生期窒息危险因素（哨兵事件、胎儿状态不安全、择期剖宫产）的婴儿围生期死亡率、围生期发病率和缺氧缺血性脑病发生率。围产期死亡率在哨兵事件组为6%，在不安全胎儿状态组为0.3%（相对危险度，2.4; 95%可信区间，1.95-2.94）。暴露于前哨事件的婴儿围产期发病率高2-6倍;缺氧缺血性脑病的发生率为10%，而不安全胎儿状态组为2.5%（相对危险度，1.93; 95%置信区间，1.49-2.52）。在择期剖宫产组没有婴儿死亡，围产期发病率，或开发encephalopathy.CONCLUSION：产时哨兵事件与围产期发病率和缺氧缺血性脑病的发病率高。
OBJECTIVE: To examine perinatal morbidity and rate of hypoxic-ischemic encephalopathy in infants exposed to intrapartum sentinel events.STUDY DESIGN: Retrospective cohort study from 2000-2005. Perinatal mortality, perinatal morbidity and rate of hypoxic-ischemic encephalopathy were compared in 3 groups of infants exposed to different risk factors for perinatal asphyxia (sentinel events, nonreassuring fetal status, elective cesarean section).RESULTS: Five hundred eighty-six infants were studied. Perinatal mortality was 6% in the sentinel event group and 0.3% in the nonreassuring fetal status group (relative risk, 2.4; 95% confidence interval, 1.95-2.94). Perinatal morbidity was 2-6 times more frequent in infants exposed to sentinel events; the incidence of hypoxic-ischemic encephalopathy was 10%, compared with 2.5% in the nonreassuring fetal status group (relative risk, 1.93; 95% confidence interval, 1.49-2.52). No infant in the elective cesarean section group died, had perinatal morbidity, or developed encephalopathy.CONCLUSION: Intrapartum sentinel events are associated with a high incidence of perinatal morbidity and hypoxic-ischemic encephalopathy.