Entorhinal Cortex Thickness across the Human Lifespan.
Entorhinal Cortex Thickness across the Human Lifespan.
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DOI：
10.1111/jon.12297
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发表时间：
2016-05
期刊：
影响因子：
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通讯作者：
Soares J
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文献类型：
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作者：
Hasan KM;Mwangi B;Cao B;Keser Z;Tustison NJ;Kochunov P;Frye RE;Savatic M;Soares J
人类内嗅皮层(ERC)连接颞叶新皮质和海马区，是记忆提取和导航所必需的。值得注意的是，在儿童和成人健康受试者的一生中，关于ERC几何测量的定量MRI工作很少。在这里，我们试图通过量化跨越90年寿命的大量受试者的ERC厚度来填补这一知识空白。我们利用多个中心(IXI、MMRR、NKI、OASIS结合NIH-Child Dev数据库和当地招募的健康受试者)的磁共振成像数据，分析了1660名2~94岁健康对照的ERC厚度的寿命轨迹。ERC厚度随年龄增长而增加，在44岁左右达到峰值，然后随年龄增长而减小。ERC厚度呈半球向右不对称，无性别差异。不同年龄段人群的平均上颌骨厚度在2.943±0.438 mm和3.525±0.355 mm之间变化。此外，在健康的老年男性中，更明显的是ERC厚度的减少。我们的报告使用了1660名健康对照的高空间分辨率脑MRI数据，提供了有关ERC在整个寿命内厚度的重要线索。我们相信，我们的报告将为未来研究与认知功能障碍相关的不同神经病理铺平道路。
Human entorhinal cortex (ERC) connects the temporal neocortex with hippocampus and is essential for memory retrieval and navigation. Markedly, there have been only few quantitative MRI works on the ERC geometric measurements in pediatric and adult healthy subjects across the lifespan. Here, we sought to fill this gap in knowledge by quantifying the ERC thickness in a very large cohort of subjects spanning nine decades of life. Using magnetic resonance imaging data from multiple centers (IXI, MMRR, NKI, OASIS combined with the NIH-Child Dev database and locally recruited healthy subjects), we analyzed the lifespan trajectory of ERC thickness in 1660 healthy controls ranging from 2 to 94 years of age. The ERC thickness increased with age, reached a peak at about 44 years and then decreased with age. ERC thickness is hemispherically rightward-asymmetric with no gender differences. Mean ERC thickness was found to vary between 2.943 ± 0.438 mm and 3.525 ± 0.355 mm across different age populations. Also more pronounced loss of the ERC thickness in healthy aging men was noticeable. Our report with high spatial resolution brain MRI data from 1660 healthy controls provided important clues about ERC thickness across lifespan. We believe that our report will pave the way for the future studies investigating distinct neural pathologies related with cognitive dysfunctions.