Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer.
Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer.
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DOI：
10.3389/fimmu.2017.01225
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发表时间：
2017
影响因子：
7.3
通讯作者：
Fokas E
中科院分区：
文献类型：
--
作者：
Martin D;Rödel F;Winkelmann R;Balermpas P;Rödel C;Fokas E
Peripheral blood leukocytosis has been implicated in promoting tumor progression leading to worse survival, but the mechanisms behind this phenomenon remain unexplored. Here, we examined the prognostic role of pretreatment white blood cell (WBC) count and clinicopathologic parameters in the context of CD8+ tumor-infiltrating lymphocytes (TIL) and myeloperoxidase+ tumor-associated neutrophils (TANs) in patients with anal squamous cell carcinoma (ASCC) treated with definitive chemoradiotherapy (CRT). After a median follow-up of 26 months, leukocytosis correlated with advanced T-stage (p < 0.001) and N-stage (p < 0.001), and predicted for worse distant-metastasis-free survival (p = 0.006), disease-free-survival (DFS, p = 0.029), and overall survival (p = 0.013). Importantly, leukocytosis was associated with a lower intraepithelial CD8+ TIL density (p = 0.014), whereas low CD8+ TIL expression in the intraepithelial compartment was associated with worse DFS (p = 0.028). Additionally, high TAN expression in the peritumoral compartment was associated with a significantly lower density of CD8+ TIL (p = 0.039), albeit, TAN expression lacked prognostic value. In conclusion, leukocytosis constitutes an important prognostic marker in ASCC patients treated with CRT. In conjunction with intratumoral TIL and TAN, these data provide for the first time important insight on the correlation of peripheral blood leukocytosis with the intratumoral immune contexture and could be relevant for future patient stratification using immunotherapies in ASCC.
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影响因子：
17.1
作者：
Highfill SL;Cui Y;Giles AJ;Smith JP;Zhang H;Morse E;Kaplan RN;Mackall CL
通讯作者：
Mackall CL
影响因子：
7.5
作者：
Caruso, RA;Bellocco, R;Inferrera, C
通讯作者：
Inferrera, C
影响因子：
6.4
作者：
De Vuyst, Hugo;Clifford, Gary M.;Franceschi, Silvia
通讯作者：
Franceschi, Silvia
影响因子：
8.8
作者：
Gilbert DC;Serup-Hansen E;Linnemann D;Høgdall E;Bailey C;Summers J;Havsteen H;Thomas GJ
通讯作者：
Thomas GJ
影响因子：
50.3
作者：
Blaisdell A;Crequer A;Columbus D;Daikoku T;Mittal K;Dey SK;Erlebacher A
通讯作者：
Erlebacher A