Effects of atorvastatin therapy on hypercholesterolernic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine
Effects of atorvastatin therapy on hypercholesterolernic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine
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DOI：
10.1016/j.lfs.2007.04.027
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发表时间：
2007-06-20
期刊：
影响因子：
6.1
通讯作者：
Seven, Arzu
中科院分区：
文献类型：
--
作者：
Bolayirli, Ibrahim Murat;Aslan, Mahmure;Seven, Arzu
高胆固醇血症的特征是血脂、一氧化氮途径和氧化应激标志物的变化。本研究旨在评估高胆固醇饮食和阿托伐他汀治疗对家兔氧化应激、脂质过氧化物和硫代巴比妥酸反应物质（TBARS）、NO途径标志物、一氧化氮（NO）和不对称二甲基精氨酸（ADMA）、同型半胱氨酸和对氧磷酶活性（PON1）的影响。将20只高胆固醇饮食喂养8周的家兔在高胆固醇饮食第4周时随机分为2组。第一组仅喂食高胆固醇饮食，而第二组则喂食相同的胆固醇饮食加阿托伐他汀（0.3 mg/kg/天），持续 4 周。高胆固醇饮食增加了兔子的总胆固醇、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）、ADMA、TBARS和脂质过氧化物水平，并降低了PON1活性和NO水平。四周的阿托伐他汀治疗显着增加了 HDL-C、PON1 活性，降低了 LDL-C、TBARS 和脂质过氧化物浓度。阿托伐他汀治疗有利于减少与高胆固醇血症相关的氧化应激，主要影响血脂和 PON1 活性。 (C) 2007 Elsevier Inc. 保留所有权利。
Hypercholesterolemia is characterized with changes in lipid profile, nitric oxide pathway and oxidative stress markers. This study is designed to evaluate the effects of hypercholesterolemic diet and atorvastatin therapy on oxidative stress, lipid peroxide and thiobarbituric acid reactive substances (TBARS), NO pathway markers, nitric oxide(NO) and asymmetric dimethylarginine (ADMA), homocysteine, and paraoxonase activity (PON1) in rabbits. Twenty rabbits fed with high-cholesterol diet for 8 weeks were randomly divided into 2 groups on the fourth week of the hypercholesterolemic diet. First group was fed with high-cholesterol diet alone, whereas the second group with the same cholesterol diet plus atorvastatin (0.3 mg/kg/day) for 4 weeks. High-cholesterol diet increased total cholesterol, low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), ADMA, TBARS and lipid peroxide levels and reduced PON1 activity and NO levels in rabbits. Four weeks of atorvastatin therapy significantly increased HDL-C, PON1 activity and reduced LDL-C, TBARS and lipid peroxide concentrations. Atorvastatin therapy is beneficial in decreasing oxidative stress related with hypercholesterolemia, mainly affecting lipid profile and PON1 activity. (C) 2007 Elsevier Inc. All rights reserved.