Iron Pathophysiology in Stroke
Iron Pathophysiology in Stroke
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DOI：
10.1007/978-981-13-9589-5_6
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Shi, Honglian
中科院分区：
文献类型：
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作者：
Almutairi, Mohammed M. A.;Xu, Grace;Shi, Honglian
缺血性和出血性中风是常见的中风类型，可导致脑损伤、神经功能缺损和死亡。所有形式的中风仍然是一个严重的健康问题，而且治疗中风的药物几乎没有成功的开发。对脑卒中病理生理的不完全理解被认为是限制这一研究进展的主要障碍。除了线粒体和产生自由基的酶外，不稳定铁也是氧化应激的重要贡献者。尽管对脑卒中中的铁调节和代谢尚未完全了解，但近年来已经取得了很大进展。例如，hepcidin最近被认为是系统铁稳态的主要调节剂，是炎症和铁调节之间的桥梁。本文综述了近年来脑卒中后铁的病理生理研究进展，重点介绍了铁代谢的分子调控和潜在的治疗靶点。
Ischemic and hemorrhagic stroke are the common types of stroke that lead to brain injury neurological deficits and mortality. All forms of stroke remain a serious health issue, and there is little successful development of drugs for treating stroke. Incomplete understanding of stroke pathophysiology is considered the main barrier that limits this research progress. Besides mitochondria and free radical-producing enzymes, labile iron is an important contributor to oxidative stress. Although iron regulation and metabolism in cerebral stroke are not fully understood, much progress has been achieved in recent years. For example, hepcidin has recently been recognized as the principal regulator of systemic iron homeostasis and a bridge between inflammation and iron regulation. This review discusses recent research progress in iron pathophysiology following cerebral stroke, focusing molecular regulation of iron metabolism and potential treatment targets.