APOA1/C3/A5 haplotype and risk of hypertriglyceridemia in Taiwanese
APOA1/C3/A5 haplotype and risk of hypertriglyceridemia in Taiwanese
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DOI：
10.1016/j.cca.2007.12.014
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发表时间：
2008-04-01
影响因子：
5
通讯作者：
Kao, Jau-Tsuen
中科院分区：
文献类型：
--
作者：
Chien, Kuo-Liong;Fang, Woei-Horng;Kao, Jau-Tsuen
Background: Apolipoprotein A5 gene (APOA5) has been shown to modulate plasma triglyceride concentrations. We investigated 2 distinct APOA1/C3/A5 haplotypes roles for hypertriglyceridemia.Methods: We recruited 308 cases of hypertriglyceridemia and 281 normal controls from a hospital. Twelve single nucleotide polymorphisms (SNPs) across the APOA1/C3/A5 gene region were genotyped.Results: One haplotype containing the minor alleles of the APOA5 (-1131T>C, c.553G>T) and APOA1 (-3013C>T,-75G>A) was more prevalent in cases than in controls (11.3% vs. 1.1%, respectively) and was statistically significantly associated with high triglycerides (adjusted odds ratio: 12.83, 95% confidence interval [CI]: 5.1-32.4, P
