CARCINOEMBRYONIC ANTIGEN-DETECTION BY IMMUNOCYTOCHEMICAL METHODS IN CARCINOMAS OF THE COLON AND STOMACH
CARCINOEMBRYONIC ANTIGEN-DETECTION BY IMMUNOCYTOCHEMICAL METHODS IN CARCINOMAS OF THE COLON AND STOMACH
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DOI：
10.1007/bf02562496
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发表时间：
1983-01-01
影响因子：
3.9
通讯作者：
PAPACHARALAMPOUS, N
中科院分区：
文献类型：
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作者：
NAKOPOULOU, L;ZINOZI, M;PAPACHARALAMPOUS, N
应用免疫过氧化物酶和免疫荧光技术对50例结肠腺癌和50例胃腺癌石蜡切片进行癌胚抗原（CEA）的研究。CEA在结肠癌（86%）中的阳性高于胃癌（76%）。免疫过氧化物酶是检测两器官CEA的较灵敏的技术。非肿瘤性结肠瘤周黏膜CEA阳性多于瘤周胃黏膜。CEA在高分化结肠癌和胃癌中较低分化癌多见，且染色强度较低分化癌强。结肠癌和胃癌中CEA的存在与疾病的分期没有关系。CEA在左结肠癌中的检出率高于右结肠癌。
CEA [carcinoembryonic antigen] was studied in paraffin sections from 50 cases of colonic and 50 cases of gastric adenocarcinoma using immunoperoxidase and immunofluorescence techniques. CEA was positive more frequently in colonic (86%) than in stomach carcinoma (76%). Immunoperoxidase was the more sensitive technique for the detection of CEA in both organs. The nonneoplastic peritumoral colonic mucosa was more often CEA positive than was the peritumoral gastric mucosa. CEA was found more often, and the intensity of the staining was stronger in well-differentiated colonic and gastric carcinoma than it was in poorly differentiated carcinoma. No relation was found between the presence of CEA in colonic and gastric carcinoma, and the stages of the disease. CEA was detected more frequently in carcinomas of the left colon than in carcinomas of the right colon.