D-amphetamine-induced behavioral sensitization: Effect of lesioning dopaminergic terminals in the medial prefrontal cortex, the amygdala and the entorhinal cortex
D-amphetamine-induced behavioral sensitization: Effect of lesioning dopaminergic terminals in the medial prefrontal cortex, the amygdala and the entorhinal cortex
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DOI：
10.1016/s0306-4522(01)00508-5
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发表时间：
2002-01-01
期刊：
影响因子：
3.3
通讯作者：
Cador, M
中科院分区：
文献类型：
--
作者：
Bjijou, Y;De Deurwaerdere, P;Cador, M
重复给药D-苯丙胺所产生的行为敏感化被认为涉及中隔核通路中的多巴胺能神经元。这一过程的诱导依赖于药物在腹侧被盖区的作用，而其表达涉及伏核的作用。我们在这里研究了除中隔核以外的多巴胺能投射在这种现象中的可能参与。我们研究了内侧前额叶皮质、杏仁核和内嗅觉皮质的多巴胺能损毁在重复外周或直接向大脑腹侧被盖区注射苯丙胺所产生的行为敏感化中的影响。反复给药安非他明引起了行为敏感化，腹侧被盖区是诱导这一过程的关键部位。这种对苯丙胺的增敏作用与吗啡发生交叉反应，并在停止治疗2周后仍可观察到。双侧6-羟基多巴胺损毁内侧前额叶皮质或杏仁核的多巴胺能终末。但不是在内嗅觉皮质。无论苯丙胺是外周给药还是直接给药到腹侧被盖区，都能阻止行为对苯丙胺的敏化和与吗啡的交叉敏化。它涉及腹侧被盖区的多巴胺能神经元，也依赖于内侧前额叶皮质和杏仁核的多巴胺能神经传递，而不依赖内嗅皮层的多巴胺能神经传递。(C)2002年IBRO。爱思唯尔科学有限公司出版。版权所有。
The behavioral sensitization produced by the repeated administration of D-amphetamine is known to involve dopaminergic neurons in the mesoaccumbens pathway. Induction of this process is dependent on action of the drug in the ventral tegmental area while its expression involves action in the nucleus accumbens. We studied here the putative involvement of dopaminergic projections other than the mesoaccumbens in this phenomenon. We examined the influence of dopaminergic lesion of the medial prefrontal cortex, the amygdala and the entorhinal cortex in the behavioral sensitization produced by repeated injections of amphetamine either peripherally or directly into the ventral tegmental area of the brain. The repeated administration of amphetamine induced a behavioral sensitization, with the ventral tegmental area a critical site for induction of the process. This sensitization to amphetamine cross-reacted with morphine and was still observed 2 weeks after cessation of the treatment. Bilateral 6-hydroxydopamine lesion of dopaminergic terminals in either the medial prefrontal cortex or the amygdala. but not in the entorhinal cortex. prevented the development of behavioral sensitization to amphetamine and the cross-sensitization with morphine, whether the amphetamine pretreatment was administered peripherally or directly into the ventral tegmental area.In conclusion, these results indicated that behavioral sensitization to amphetamine. which involves dopaminergic neurons of the ventral tegmental area, is also dependent on dopaminergic neuro transmission of the medial prefrontal cortex and amygdala but not of the entorhinal cortex. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.