ADRIAMYCIN EFFECTS ON INSULIN-SECRETION, CA-2+ MOVEMENTS AND GLUCOSE-OXIDATION IN PANCREATIC-ISLET CELLS
ADRIAMYCIN EFFECTS ON INSULIN-SECRETION, CA-2+ MOVEMENTS AND GLUCOSE-OXIDATION IN PANCREATIC-ISLET CELLS
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DOI：
10.1016/0031-6989(85)90097-9
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
GOORMAGHTIGH, E
中科院分区：
文献类型：
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作者：
DELEERS, M;GOORMAGHTIGH, E
本实验观察了阿霉素对大鼠胰岛B细胞胰岛素分泌、钙运动和葡萄糖氧化的影响，以确定阿霉素除心脏毒性外的其他毒性作用。治疗剂量的阿霉素可能对内分泌功能具有高度毒性。这些影响的药物与呼吸链的相互作用进行了讨论。
The effects of Adriamycin on rat islet B cells were investigated for insulin secretion, Ca movements and glucose oxidation in order to determine other toxic effect of the new antineoplastic drug than cardiotoxic effects. Therapeutic doses of Adriamycin could be highly toxic for endorine secretory function. These effects are discussed in terms of interactions of the drug with the respiratory chain.