Changes in subcortical structures in early- versus late-onset Alzheimer's disease
Changes in subcortical structures in early- versus late-onset Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2013.01.001
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发表时间：
2013-07-01
影响因子：
4.2
通讯作者：
Na, Duk L.
中科院分区：
文献类型：
--
作者：
Cho, Hanna;Seo, Sang Won;Na, Duk L.
据报道，早发性阿尔茨海默病（EOAD）患者在神经心理学和神经影像学方面与晚发性阿尔茨海默病（LOAD）患者不同。在这项研究中，我们的目的是比较6个皮质下结构（杏仁核，海马，丘脑，壳核，苍白球，尾状核）的纵向体积变化的EOAD和负载之间的患者3年。我们前瞻性招募了36例可能患有阿尔茨海默病的患者（14例EOAD，22例LOAD）和14例正常对照组。我们分析了皮质下结构的体积使用自动表面为基础的方法。基线时，EOAD和LOAD患者的皮质下结构体积无差异。然而，在3年的纵向随访中，EOAD患者的尾状核、壳核和丘脑体积下降比LOAD患者更快，这与神经心理学结果一致。我们的研究结果表明，认知储备理论可能适用于解释不同的发病年龄的基底节和丘脑的体积下降率。(C)2013 Elsevier Inc. All rights reserved.
Patients with early-onset Alzheimer's disease (EOAD) are reported to be different from those with late-onset Alzheimer's disease (LOAD) in terms of neuropsychological and neuroimaging findings. In this study, we aimed to compare the longitudinal volume changes of 6 subcortical structures (the amygdala, hippocampus, thalamus, putamen, globus pallidus, and caudate nucleus) between patients with EOAD and LOAD for 3 years. We prospectively recruited 36 patients with probable Alzheimer's disease (14 EOAD, 22 LOAD) and 14 normal control subjects. We analyzed the volume of subcortical structures using an automatic surface-based method. At baseline, there were no differences in the volumes of subcortical structures between patients with EOAD and LOAD. However, over 3 years of longitudinal follow-up, patients with EOAD showed more rapid volumetric decline in the caudate, putamen, and thalamus than patients with LOAD, which is consistent with neuropsychological results. Our findings suggested that the cognitive reserve theory might be applicable to explain different decline rates of the volumes of the basal ganglia and thalamus according to onset age. (C) 2013 Elsevier Inc. All rights reserved.