Innate Immunity Protein IFITM3 in Alzheimer's Disease
Innate Immunity Protein IFITM3 in Alzheimer's Disease
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DOI：
10.1089/dna.2021.0585
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发表时间：
2021-08-31
影响因子：
3.1
通讯作者：
Hur, Ji-Yeun
中科院分区：
文献类型：
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作者：
Hur, Ji-Yeun
先天免疫中的几个基因与阿尔茨海默病（AD）有关。然而，先天免疫对淀粉样蛋白β（A β）产生的影响，这使得淀粉样蛋白斑块在AD大脑中，以前是未知的。最近，抗病毒蛋白干扰素诱导的跨膜蛋白3（IFITM 3）已被确定为一种新的γ-分泌酶调节蛋白A β的生产。在这篇综述中，先天免疫如何通过IFITM 3-γ-分泌酶复合物调节A β的产生，并有助于AD的发病机制进行了讨论。
Several genes in innate immunity have been implicated in Alzheimer's disease (AD). However, the effect of innate immunity on amyloid beta (A beta) production, which makes amyloid plaques in AD brains, was previously not known. Recently, the antiviral protein interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel gamma-secretase modulatory protein for A beta production. In this review, the mechanisms of how innate immunity modulates A beta production via IFITM3-gamma-secretase complexes and contributes to AD pathogenesis are discussed.