A DUAL MECHANOSENSORY AND CHEMOSENSORY NEURON IN CAENORHABDITIS-ELEGANS
A DUAL MECHANOSENSORY AND CHEMOSENSORY NEURON IN CAENORHABDITIS-ELEGANS
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DOI：
10.1073/pnas.90.6.2227
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发表时间：
1993-03-15
影响因子：
11.1
通讯作者：
HORVITZ, HR
中科院分区：
文献类型：
--
作者：
KAPLAN, JM;HORVITZ, HR
在轻轻触摸它的鼻子后，秀丽隐杆线虫停止向前运动并开始后退。在这里，我们表明，三类神经元（ASH，FLP和OLQ）的感觉触摸到鼻子，因此需要这种回避反应。ASH、FLP和OLQ具有包含轴丝纤毛的感觉末梢。有缺陷的纤毛感觉末梢的突变动物以及缺乏ASH、FLP和OLQ的激光操作动物对触摸鼻子没有反应。结合其他人以前的工作，这些结果表明C.线虫具有至少五种形态上不同的机械感觉神经元。有趣的是，ASH神经元也充当化学感觉神经元;它介导对有害化学物质的回避。由于ASH具有化学感觉和机械感觉模式，因此该神经元可能在功能上类似于介导疼痛感觉的脊椎动物伤害感受器。
After light touch to its nose, the nematode Caenorhabditis elegans halts forward locomotion and initiates backing. Here we show that three classes of neurons (ASH, FLP, and OLQ) sense touch to the nose and hence are required for this avoidance response. ASH, FLP, and OLQ have sensory endings that contain axonemal cilia. Mutant animals that have defective ciliated sensory endings as well as laser-operated animals that lack ASH, FLP, and OLQ fail to respond to touch to the nose. Together with the previous work of others, these results demonstrate that C. elegans has at least five morphologically distinct classes of mechanosensory neurons. Interestingly, the ASH neuron also acts as a chemosensory neuron; it mediates the avoidance of noxious chemicals. Since ASH possesses both chemosensory and mechanosensory modalities, this neuron might be functionally analogous to vertebrate nociceptors, which mediate the sensation of pain.