Mantle cell/centrocytic lymphoma: molecular and phenotypic analysis including analysis of the bcl-1 major translocation cluster by PCR.

Mantle cell/centrocytic lymphoma: molecular and phenotypic analysis including analysis of the bcl-1 major translocation cluster by PCR.
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套细胞/中心细胞淋巴瘤:分子和表型分析,包括通过 PCR 分析 bcl-1 主要易位簇。

DOI:
10.1007/978-3-642-79275-5_39
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发表时间:
1995
影响因子:
--
通讯作者:
Swerdlow,SH
Swerdlow,SH
中科院分区:
医学3区
文献类型:
--
作者:
Williams,ME;Zukerberg,LR;Harris,NL;Yang,WI;Arnold,A;Finkelstein,SD;Swerdlow,SH

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套细胞/中心细胞淋巴瘤(MCL)是一种生物学和临床上不同的非霍奇金淋巴瘤(NHL)亚型,其特征为具有不规则核的小淋巴细胞和弥漫性、模糊结节或套区生长模式[1,2]。肿瘤细胞通常对CD 5、泛B细胞抗原CD 19和CD 20以及表面IgM和IgD呈阳性,但对CD 10和CD 23呈阴性。临床特征包括男性占优势,发病年龄中位数为64岁,大多数患者表现为晚期疾病。外周血、骨髓和累及胃肠道或Waldeyer环的淋巴结疾病是常见的[1,2]。中位生存期约为30-40个月。MCL估计占所有NHL的约4-7%。
Mantle cell/centrocytic lymphoma (MCL) is a biologically and clinically distinct subtype of non-Hodgkin’s lymphoma (NHL) characterized by small lymphocytes with irregular nuclei and a diffuse, vaguely nodular, or mantle zone growth pattern [1, 2]. The neoplastic cells are typically positive for CD5, the pan-B cell antigens CD19 and CD20, and surface IgM and IgD, but negative for CD10 and CD23. Clinical features include male predominance, a median age of onset of 64 years, and presentation with advanced stage disease in the majority of patients. Peripheral blood, bone marrow, and extranodal disease involving the gastrointestinal tract or Waldeyer’s ring is common [1, 2]. The median survival is approximately 30–40 months. MCL is estimated to comprise about 4–7% of all NHL.
DOI: 10.1182/blood.v82.8.2289.bloodjournal8282289
发表时间: 1993-10
期刊: Blood
影响因子: 20.3
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发表时间: 1991-11-01
影响因子: 11.1
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