Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity
Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity
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DOI：
10.1093/gerona/57.3.b109
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发表时间：
2002-03-01
影响因子：
5.1
通讯作者：
Johnson, TE
中科院分区：
文献类型：
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作者：
Cypser, JR;Johnson, TE
我们在这里证明线虫秀丽线虫表现出广泛的兴奋能力，兴奋作用是通过暴露于锁定剂量的其他有害的化学或物理制剂来诱导有益的影响。高温以及高压氧或胡桃仁(一种产生活性氧的化学物质)的预处理显著增加了对相同挑战的抵抗力，胡桃酮和氧气之间的交叉耐受性也被观察到，同样的高温或氧气预处理方案可以诱导随后的应激抵抗，也可以延长正常衰老人群的预期寿命和最长寿命。用紫外线或电离辐射进行预处理并不能增强随后的抵抗力，也不能延长寿命。在剂量反应研究中，诱导的耐热性与诱导的预期寿命的增加是平行的，这与共同的起源是一致的。
We demonstrate here that the nematode Caenorhabditis elegans displays broad hormetie abilities, Hormesis, is the induction of beneficial effects by exposure to lock doses of otherwise harmful chemical or physical agents. Heat as well as pretreatment with hyperbaric oxygen or juglone (a chemical that generates reactive oxygen species) Significantly increased resistance to the Same challenge, Cross-tolerance between juglone and oxygen was also observed, The same heat or oxygen pretreatment regimens that induced subsequent stress resistance also increased life expectancy and maximum life span of populations undergoing normal aging. Pretreatment with ultraviolet or ionizing radiation did not promote subsequent resistance or increased longevity. In dose-response studies, induced thermotolerance paralleled the induced increase in life expectancy, which is consistent with a common origin.