Increased sympathetic activation in idiopathic orthostatic intolerance - Role of systemic adrenoreceptor sensitivity
Increased sympathetic activation in idiopathic orthostatic intolerance - Role of systemic adrenoreceptor sensitivity
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DOI：
10.1161/hy1201.097202
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发表时间：
2002-01-01
期刊：
影响因子：
8.3
通讯作者：
Robertson, D
中科院分区：
文献类型：
--
作者：
Jordan, J;Shannon, JR;Robertson, D
特发性立位不耐受（OI）的特征是站立时出现肾上腺素能症状。中枢交感神经紧张或肾上腺素受体敏感性的改变可能导致这种综合征。在OI患者和对照受试者中，我们测定了在曲美沙芬神经节阻滞之前和期间递增推注剂量的异丙肾上腺素和苯肾上腺素后心率（HR）和收缩压（SBP）的变化。收缩压降低17 ± 1.6 mm Hg，对照组降低3.9 ± 3.8 mm Hg（P
Idiopathic orthostatic intolerance (OI) is characterized by adrenergic symptoms with standing. Changes in central sympathetic tone or in adrenoreceptor sensitivity could contribute to this syndrome. In OI patients and control subjects, we determined heart rate (HR) and systolic blood pressure (SBP) changes after incremental bolus doses of isoproterenol and phenylephrine before and during ganglionic blockade with trimethaphan. SBP decreased by 17 +/- 1.6 mm Hg in patients and 3.9 +/- 3.8 mm Hg in control subjects (P