White matter hyperintensity on magnetic resonance imaging: clinical and neuroanatomic correlates in the depressed elderly.
White matter hyperintensity on magnetic resonance imaging: clinical and neuroanatomic correlates in the depressed elderly.
复制标题
磁共振成像白质高信号：抑郁老年人的临床和神经解剖学相关性。
DOI：
10.1176/jnp.1.2.135
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Weiner,RD
中科院分区：
文献类型：
--
作者：
Coffey,CE;Figiel,GS;Djang,WT;Saunders,WB;Weiner,RD
In a prospective study of depressed elderly patients referred for electroconvulsive therapy (ECT), subcortical white matter hyperintensity (WMH) was seen in all 51 patients 60 years or older who received magnetic resonance imaging (MRI) prior to treatment. In over half of the patients the WMH was formally rated as at least moderately severe, and it was commonly associated with other structural brain changes. The majority (80%) of patients had late-age-onset depression, suggesting that structural brain changes may interact with aging to facilitate the emergency of depression in late life.
