Characterization of non-calcified coronary atherosclerotic plaque by multi-detector row CT: Comparison to IVUS
Characterization of non-calcified coronary atherosclerotic plaque by multi-detector row CT: Comparison to IVUS
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DOI：
10.1016/j.atherosclerosis.2006.01.013
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发表时间：
2007-01-01
期刊：
影响因子：
5.3
通讯作者：
Daniel, Werner G.
中科院分区：
文献类型：
--
作者：
Pohle, Karsten;Achenbach, Stephan;Daniel, Werner G.
多探测器行计算机断层扫描 (MDCT) 可实现冠状动脉的非侵入性可视化。已经描述了可视化和有限地表征非钙化冠状动脉粥样硬化斑块的能力。我们研究了通过 16 层 MDCT 确定的非钙化斑块的 CT 衰减，并与血管内超声 (IVUS) 进行比较。方法和结果：通过对比增强 16 层 CT 对 32 名患者进行了研究。此外，还对一根冠状动脉进行了 IVUS（机动回拉）（LM+LAD：22，LM+LCX：4，RCA：6）。在冠状动脉系统内的 252 个部位，MDCT 和 IVUS 都可以识别非钙化动脉粥样硬化斑块，使用中心放置的感兴趣区域测量斑块内的 CT 衰减，并将其与 IVUS 中相应位置斑块的外观相关联。与 IVUS 中高回声外观相对应的斑块内平均 CT 衰减为 121 +/- 34 HU (n = 76)。与低回声外观相对应的斑块内的平均 CT 衰减为 58 +/- 43 HU (n = 176，p < 0.001)。然而，两组中MDCT测量的密度值存在显着重叠。结论：IVUS中低回声和高回声外观的动脉粥样硬化病变内的平均CT衰减存在显着差异。然而，我们观察到斑块类型之间的衰减值存在大量重叠，因此基于 CT 衰减来区分“易损”和“稳定”斑块是值得怀疑的。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
Multi-detector row Computed Tomography (MDCT) permits non-invasive visualization of the coronary arteries. The ability to visualize and, with limitations, to characterize non-calcified coronary atherosclerotic plaque has been described. We investigated the CT attenuation of non-calcified plaques as determined by 16-slice MDCT in comparison to intravascular ultrasound (IVUS).Methods and results: Thirty-two patients were investigated by contrast-enhanced 16-slice CT. In addition, IVUS of one coronary artery (motorized pullback) was performed (LM+LAD: 22, LM+LCX: 4, RCA: 6). At 252 sites within the coronary system, in which non-calcified atherosclerotic plaque could be identified both in MDCT and IVUS, the CT attenuation within the plaque was measured using a centrally placed region of interest and correlated to the appearance of the plaque in IVUS at the corresponding location. The mean CT attenuation within plaque that corresponded to hyper-echogenic appearance in IVUS was 121 +/- 34 HU (n = 76). The mean CT attenuation within plaque that corresponded to hypo-echogenic appearance was 58 +/- 43 HU (n = 176, p < 0.001). However, there was substantial overlap of the density values measured by MDCT in the two groups.Conclusions: A significant difference of the mean CT attenuation within atherosclerotic lesions of hypo-echogenic and hyper-echogenic appearance in IVUS could be observed. However, we observed substantial overlap of attenuation values between plaque types so that the differentiation of "vulnerable" and "stable" plaques based on their CT attenuation is doubtful. (c) 2006 Elsevier Ireland Ltd. All rights reserved.