INFLAMMATION - IMAGING WITH TC-99M HMPAO-LABELED LEUKOCYTES
INFLAMMATION - IMAGING WITH TC-99M HMPAO-LABELED LEUKOCYTES
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DOI：
10.1148/radiology.166.3.3340775
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发表时间：
1988-03-01
期刊：
影响因子：
19.7
通讯作者：
KELLY, JD
中科院分区：
文献类型：
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作者：
RODDIE, ME;PETERS, AM;KELLY, JD
用~(99m)TcmHMPAO标记的白细胞对100例患者进行了检测，其中疑似炎症性肠病32例，不明原因发热17例，疑似腹部脓毒症21例，疑似骨脓毒症20例，支气管扩张7例，近期心肌梗死3例。随后被证明没有炎症性肠病的患者的活性分布类似于先前对铟-111标记的白细胞的描述。然而，在这项研究中，在早期(1-3小时)和晚期(24小时)的观察中，也可以看到肾脏和膀胱中的活动，偶尔也可以看到胆囊中的活动，而在晚期观察中，也可以在结肠中看到活动。注射后30min，炎症性病变即可见~(99m)Tc标记的粒细胞迁移，4h后仍未见正常肠道活动。99m标记白细胞检测炎症的敏感性为100%，特异性为95%。
Leukocytes labeled with technetium-99m hexamethylpropyleneamine oxime (HMPAO) were used in 100 patients: 32 with suspected inflammatory bowel disease, 17 with fever of unknown origin, 21 with suspected abdominal sepsis, 20 with suspected bone sepsis, seven with bronchiectasis, and three with recent myocardial infarction. The distribution of activity in patients subsequently shown not to have inflammatory bowel disease was similar to that previously described for indium-111-labeled leukocytes. However, in this study, activity was also seen in the kidneys and bladder and occasionally the gallbladder on both early (1-3 hours) and late (24 hours) views, and in the colon in late views. Migration of Tc-99m-labeled granulocytes was seen in inflammatory disease as early as 30 minutes after injection, while normal bowel activity was not seen before 4 hours. The sensitivity of Tc-99m-labeled leukocytes in the detection of inflammation was 100%, the specificity was 95%.