The effect of coordination mode on use-dependent plasticity
The effect of coordination mode on use-dependent plasticity
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DOI：
10.1016/j.clinph.2007.04.020
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发表时间：
2007-08-01
影响因子：
4.7
通讯作者：
Byblow, Winston D.
中科院分区：
文献类型：
--
作者：
Ackerley, Suzanne J.;Stinear, Cathy M.;Byblow, Winston D.
目的：探讨协调模式在初级运动皮质（MI）使用依赖可塑性（use-dependent plasticity， UDP）产生中的作用。方法：10名健康志愿者在训练前进行与经颅磁刺激（TMS）相反方向的快节奏重复拇指运动30分钟。这个练习是在两个独立的阶段用1赫兹的听觉节拍器同步或切分的。记录3块拇指内肌的运动诱发电位（MEPs），以评估皮质运动兴奋性的变化。结果：同步运动练习和切分运动练习均引起tms诱发的拇指运动方向的变化，偏离基线方向，向训练方向移动。同步而非切分运动练习后，MEP振幅增加。运动方向和皮质运动兴奋性的改变持续至少30分钟。结论：UDP可在存在或不存在皮质性兴奋性变化的情况下引起。意义：与外部起搏同步的运动练习可以促进UDP，促进皮质运动输出减少的患者（如卒中）的皮质运动兴奋性。与外部起搏同时进行的训练可能会促进UDP，但不会增加皮质运动性兴奋性。这可能与以适应不良可塑性为特征的疾病个体有关。(c) 2007年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To evaluate the role of coordination mode on the generation of use-dependent plasticity (UDP) within the primary motor cortex (MI).Methods: Ten healthy volunteers performed brisk repetitive thumb movements for 30 min in the opposite direction to those evoked by transcranial magnetic stimulation (TMS) prior to training. This practice was synchronized or syncopated with a 1 Hz auditory metronome in two separate sessions. Motor evoked potentials (MEPs) were recorded from 3 intrinsic thumb muscles, to assess changes in corticomotor excitability.Results: Both synchronized and syncopated motor practice induced changes in the direction of TMS-evoked thumb movements, away from the baseline direction toward the trained direction. MEP amplitude increased following synchronized, but not syncopated, motor practice. Changes in movement direction and corticomotor excitability lasted for at least 30 minutes.Conclusions: UDP can be elicited in the presence or absence of changes in corticomotor excitability.Signifieance: Motor practice that is synchronized with external pacing may promote UDP and facilitate corticomotor excitability in patient populations with reduced corticomotor output, such as stroke. Training that is syncopated with external pacing may promote UDP without increasing corticomotor excitability. This could be relevant for individuals with disorders characterized by maladaptive plasticity. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.