Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis
Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis
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DOI：
10.1016/j.joca.2006.07.007
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发表时间：
2007-02-01
影响因子：
7
通讯作者：
Kaufman, K. R.
中科院分区：
文献类型：
--
作者：
Koff, M. F.;Amrami, K. K.;Kaufman, K. R.
Objective: The transverse relaxation time constant, T-2, of articular cartilage has been proposed as a biomarker for osteoarthritis (OA). Previous studies have not clearly defined the relationship between cartilage T-2 values and clinical methods of grading CA or known factors associated with OA. This study compared T-2 values of patellar cartilage grouped by radiographic stage of patello-femoral OA and by body mass index (BMI).Methods: T-2 values of patellar cartilage were calculated for 113 subjects using images acquired on a 1.5 T clinical scanner. Radiographs of the patello-femoral joint were graded for CA grading using the Kellgren-Lawrence scale.Results: No differences of T-2 values were found across the stages of CA (P= 0.25), but the factor of BMI did have a significant effect (P < 0.0001) on T-2 value.Conclusions: The results indicate the T-2 values are not sensitive to changes in radiographic stages of OA. In addition, differences of T-2 values with BMI signify structural changes occurring within the patello-femoral joint and that BMI maybe considered a factor for a potential increase of T-2 values. Future studies comparing different CA grading methods with T-2 mapping may highlight the sensitivity of T-2 mapping in a clinical setting. (C) 2006 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
